Source:http://linkedlifedata.com/resource/pubmed/id/16274934
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2006-2-27
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| pubmed:abstractText |
The present study in the South American rodent Octodon degus shows for the first time that the postnatal development of hypothalamic-pituitary-adrenal axis function in this semi-precocial species differs from that of altricial rodents, i.e. rats or mice, in several aspects. Our experiments revealed a particular pattern of hypothalamic-pituitary-adrenal axis activity during the first 3 weeks of life characterized by (i) a period of low plasma glucocorticoid concentrations, during which (ii) brief stress exposure (1 h parental separation) is able to elevate glucocorticoids significantly. In addition, (iii) repeated stress exposure (1 h parental separation daily) during the first 3 weeks of life resulted in females, but not in males, in an attenuated separation-induced increase of glucocorticoids, and a higher behavioural activity in both sexes at postnatal day 21. These data indicate that parental separation early in life acts as a 'strong' stressor in this species, which on the long run can alter endocrine stress response at the time of weaning in a sex-specific manner. These findings support the role of the hypothalamic-pituitary-adrenal axis as one of the key factors mediating the effects of early life stress on the neuronal network and behaviour in O. degus.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0306-4530
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
31
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
361-72
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:16274934-Acute Disease,
pubmed-meshheading:16274934-Adaptation, Physiological,
pubmed-meshheading:16274934-Adaptation, Psychological,
pubmed-meshheading:16274934-Age Factors,
pubmed-meshheading:16274934-Animals,
pubmed-meshheading:16274934-Behavior, Animal,
pubmed-meshheading:16274934-Chronic Disease,
pubmed-meshheading:16274934-Corticosterone,
pubmed-meshheading:16274934-Disease Models, Animal,
pubmed-meshheading:16274934-Fathers,
pubmed-meshheading:16274934-Female,
pubmed-meshheading:16274934-Glucocorticoids,
pubmed-meshheading:16274934-Hydrocortisone,
pubmed-meshheading:16274934-Hypothalamo-Hypophyseal System,
pubmed-meshheading:16274934-Male,
pubmed-meshheading:16274934-Mothers,
pubmed-meshheading:16274934-Octodon,
pubmed-meshheading:16274934-Pituitary-Adrenal System,
pubmed-meshheading:16274934-Sex Factors,
pubmed-meshheading:16274934-Social Environment,
pubmed-meshheading:16274934-Social Isolation,
pubmed-meshheading:16274934-Stress, Psychological
|
| pubmed:year |
2006
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| pubmed:articleTitle |
Endocrine and behavioural plasticity in response to juvenile stress in the semi-precocial rodent Octodon degus.
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| pubmed:affiliation |
Department of Zoology/Developmental Neurobiology, Institute of Biology, Otto von Guericke University Magdeburg, Brenneckestrasse 6, 39118 Magdeburg, Germany. michael.gruss@nat.uni-magdeburg.de
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|