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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2005-12-21
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pubmed:abstractText |
The infiltration, accumulation and degranulation of eosinophils in the lung represents a hallmark of active asthma. In vivo or in vitro eosinophil activation triggers the secretion of the antiapoptotic cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF). We now identify Pin1, a cis-trans isomerase, as an essential component of the ribonucleoprotein complex responsible for GM-CSF mRNA stabilization, cytokine secretion and the survival of activated eosinophils. Pin1 regulated the association of the AU-rich element-binding proteins AUF1 and hnRNP C with GM-CSF mRNA, accelerating or slowing decay, respectively. These data indicate Pin1 is a key mediator of GM-CSF production.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1529-2908
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1280-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16273101-Allergens,
pubmed-meshheading:16273101-Cell Survival,
pubmed-meshheading:16273101-Cells, Cultured,
pubmed-meshheading:16273101-Eosinophils,
pubmed-meshheading:16273101-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:16273101-Heterogeneous-Nuclear Ribonucleoprotein D,
pubmed-meshheading:16273101-Humans,
pubmed-meshheading:16273101-Hyaluronic Acid,
pubmed-meshheading:16273101-Peptidylprolyl Isomerase,
pubmed-meshheading:16273101-RNA, Messenger,
pubmed-meshheading:16273101-RNA Stability
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pubmed:year |
2005
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pubmed:articleTitle |
The peptidyl-prolyl isomerase Pin1 regulates the stability of granulocyte-macrophage colony-stimulating factor mRNA in activated eosinophils.
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pubmed:affiliation |
The Waisman Center for Developmental Disabilities, the Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine, Madison, Wisconsin 53705, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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