rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2005-11-7
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pubmed:abstractText |
Smoking is a major cause of death and often initiates in adolescence. Mutations in CYP2A6 slow metabolism of nicotine to cotinine. Haploinsufficiency in adults is associated with lower cigarette consumption, lower cotinine level and higher quit rates. Other genes are also implicated in smoking behaviour. We explored smoking behaviour and cotinine levels in relation to genotypes in adolescents.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aryl Hydrocarbon Hydroxylases,
http://linkedlifedata.com/resource/pubmed/chemical/Cotinine,
http://linkedlifedata.com/resource/pubmed/chemical/DRD4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Mixed Function Oxygenases,
http://linkedlifedata.com/resource/pubmed/chemical/Monoamine Oxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Nicotine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Serotonin, 5-HT2A,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D4,
http://linkedlifedata.com/resource/pubmed/chemical/coumarin 7-hydroxylase
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1744-6872
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
839-50
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16272956-Adolescent,
pubmed-meshheading:16272956-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:16272956-Cotinine,
pubmed-meshheading:16272956-Gene Frequency,
pubmed-meshheading:16272956-Genotype,
pubmed-meshheading:16272956-Humans,
pubmed-meshheading:16272956-Longitudinal Studies,
pubmed-meshheading:16272956-Mixed Function Oxygenases,
pubmed-meshheading:16272956-Monoamine Oxidase,
pubmed-meshheading:16272956-Nicotine,
pubmed-meshheading:16272956-Polymorphism, Genetic,
pubmed-meshheading:16272956-Receptor, Serotonin, 5-HT2A,
pubmed-meshheading:16272956-Receptors, Dopamine D4,
pubmed-meshheading:16272956-Smoking
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pubmed:year |
2005
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pubmed:articleTitle |
CYP2A6, MAOA, DBH, DRD4, and 5HT2A genotypes, smoking behaviour and cotinine levels in 1518 UK adolescents.
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pubmed:affiliation |
Human Genetics Division, Duthie Building, Southampton General Hospital, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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