|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
10
|
|
pubmed:dateCreated |
2005-11-7
|
|
pubmed:abstractText |
Immunity and tumor protection in mice transgenic for human MUC.1, a glycoprotein expressed in the majority of cancers of epithelial origin in humans, were induced by vaccination with B lymphocytes genetically programmed to activate MUC.1-specific CD4 T cells. Their activation required a functional cooperation between two Th cells, one specific for a self (MUC.1) and the other for a nonself T cell determinant. The immunological switch provided by Th-Th cooperation was sufficient to induce MUC.1-specific CD4 and CD8 T cell responses in MUC.1-transgenic mice, and protect them permanently from tumor growth. CD4 T cells specific for MUC.1 lacked cytolytic function, but produced IFN-gamma upon restimulation with Ag. We conclude that immunity against tumor self-Ags and tumor protection can be regulated exploiting an inherent property of the immune system.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0022-1767
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
175
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
6551-9
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:16272309-Amino Acid Sequence,
pubmed-meshheading:16272309-Animals,
pubmed-meshheading:16272309-Antigens,
pubmed-meshheading:16272309-Antigens, Neoplasm,
pubmed-meshheading:16272309-B-Lymphocytes,
pubmed-meshheading:16272309-CD4-Positive T-Lymphocytes,
pubmed-meshheading:16272309-Cell Line, Tumor,
pubmed-meshheading:16272309-Cytotoxicity, Immunologic,
pubmed-meshheading:16272309-Glycoproteins,
pubmed-meshheading:16272309-Humans,
pubmed-meshheading:16272309-Immunization,
pubmed-meshheading:16272309-Interferon-gamma,
pubmed-meshheading:16272309-Lymphocyte Activation,
pubmed-meshheading:16272309-Lymphocyte Cooperation,
pubmed-meshheading:16272309-Mice,
pubmed-meshheading:16272309-Mice, Inbred C57BL,
pubmed-meshheading:16272309-Mice, Transgenic,
pubmed-meshheading:16272309-Mucin-1,
pubmed-meshheading:16272309-Mucins,
pubmed-meshheading:16272309-Neoplasms, Experimental,
pubmed-meshheading:16272309-T-Lymphocytes, Cytotoxic
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
The cooperation between two CD4 T cells induces tumor protective immunity in MUC.1 transgenic mice.
|
|
pubmed:affiliation |
Laboratory of Immunology, Department of Medicine and Cancer Center, University of California-San Diego, La Jolla, CA 92093, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|
