| pubmed-article:16272123 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16272123 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:16272123 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:16272123 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:16272123 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:16272123 | lifeskim:mentions | umls-concept:C0439784 | lld:lifeskim |
| pubmed-article:16272123 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:16272123 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:16272123 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:16272123 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:16272123 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:16272123 | pubmed:issue | 5749 | lld:pubmed |
| pubmed-article:16272123 | pubmed:dateCreated | 2005-11-7 | lld:pubmed |
| pubmed-article:16272123 | pubmed:abstractText | The molecular pathways involved in retrograde signal transduction at synapses and the function of retrograde communication are poorly understood. Here, we demonstrate that postsynaptic calcium 2+ ion (Ca2+) influx through glutamate receptors and subsequent postsynaptic vesicle fusion trigger a robust induction of presynaptic miniature release after high-frequency stimulation at Drosophila neuromuscular junctions. An isoform of the synaptotagmin family, synaptotagmin 4 (Syt 4), serves as a postsynaptic Ca2+ sensor to release retrograde signals that stimulate enhanced presynaptic function through activation of the cyclic adenosine monophosphate (cAMP)-cAMP-dependent protein kinase pathway. Postsynaptic Ca2+ influx also stimulates local synaptic differentiation and growth through Syt 4-mediated retrograde signals in a synapse-specific manner. | lld:pubmed |
| pubmed-article:16272123 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16272123 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16272123 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16272123 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16272123 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16272123 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16272123 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16272123 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:16272123 | pubmed:issn | 1095-9203 | lld:pubmed |
| pubmed-article:16272123 | pubmed:author | pubmed-author:YoshiharaMoto... | lld:pubmed |
| pubmed-article:16272123 | pubmed:author | pubmed-author:LittletonJ... | lld:pubmed |
| pubmed-article:16272123 | pubmed:author | pubmed-author:AdolfsenBillB | lld:pubmed |
| pubmed-article:16272123 | pubmed:author | pubmed-author:GalleKathleen... | lld:pubmed |
| pubmed-article:16272123 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:16272123 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:16272123 | pubmed:volume | 310 | lld:pubmed |
| pubmed-article:16272123 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16272123 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16272123 | pubmed:pagination | 858-63 | lld:pubmed |
| pubmed-article:16272123 | pubmed:dateRevised | 2010-12-3 | lld:pubmed |
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| pubmed-article:16272123 | pubmed:meshHeading | pubmed-meshheading:16272123... | lld:pubmed |
| pubmed-article:16272123 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:16272123 | pubmed:articleTitle | Retrograde signaling by Syt 4 induces presynaptic release and synapse-specific growth. | lld:pubmed |
| pubmed-article:16272123 | pubmed:affiliation | Picower Institute for Learning and Memory, Department of Biology, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. motojiro@mit.edu | lld:pubmed |
| pubmed-article:16272123 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16272123 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:16272123 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16272123 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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