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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5749
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pubmed:dateCreated |
2005-11-7
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pubmed:abstractText |
The molecular pathways involved in retrograde signal transduction at synapses and the function of retrograde communication are poorly understood. Here, we demonstrate that postsynaptic calcium 2+ ion (Ca2+) influx through glutamate receptors and subsequent postsynaptic vesicle fusion trigger a robust induction of presynaptic miniature release after high-frequency stimulation at Drosophila neuromuscular junctions. An isoform of the synaptotagmin family, synaptotagmin 4 (Syt 4), serves as a postsynaptic Ca2+ sensor to release retrograde signals that stimulate enhanced presynaptic function through activation of the cyclic adenosine monophosphate (cAMP)-cAMP-dependent protein kinase pathway. Postsynaptic Ca2+ influx also stimulates local synaptic differentiation and growth through Syt 4-mediated retrograde signals in a synapse-specific manner.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
4
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pubmed:volume |
310
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
858-63
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pubmed:dateRevised |
2010-12-3
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pubmed:meshHeading |
pubmed-meshheading:16272123-Animals,
pubmed-meshheading:16272123-Animals, Genetically Modified,
pubmed-meshheading:16272123-Calcium,
pubmed-meshheading:16272123-Cell Differentiation,
pubmed-meshheading:16272123-Cyclic AMP,
pubmed-meshheading:16272123-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:16272123-Drosophila,
pubmed-meshheading:16272123-Egtazic Acid,
pubmed-meshheading:16272123-Embryo, Nonmammalian,
pubmed-meshheading:16272123-Excitatory Postsynaptic Potentials,
pubmed-meshheading:16272123-Feedback, Physiological,
pubmed-meshheading:16272123-Models, Neurological,
pubmed-meshheading:16272123-Mutation,
pubmed-meshheading:16272123-Neuromuscular Junction,
pubmed-meshheading:16272123-Neuronal Plasticity,
pubmed-meshheading:16272123-Presynaptic Terminals,
pubmed-meshheading:16272123-Receptors, Glutamate,
pubmed-meshheading:16272123-Signal Transduction,
pubmed-meshheading:16272123-Synapses,
pubmed-meshheading:16272123-Synaptic Membranes,
pubmed-meshheading:16272123-Synaptic Transmission,
pubmed-meshheading:16272123-Synaptic Vesicles
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pubmed:year |
2005
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pubmed:articleTitle |
Retrograde signaling by Syt 4 induces presynaptic release and synapse-specific growth.
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pubmed:affiliation |
Picower Institute for Learning and Memory, Department of Biology, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. motojiro@mit.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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