| pubmed-article:16271741 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16271741 | lifeskim:mentions | umls-concept:C1325725 | lld:lifeskim |
| pubmed-article:16271741 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:16271741 | lifeskim:mentions | umls-concept:C0221102 | lld:lifeskim |
| pubmed-article:16271741 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16271741 | pubmed:dateCreated | 2006-1-23 | lld:pubmed |
| pubmed-article:16271741 | pubmed:abstractText | We recently showed that both replicating and resting cells cultivated with ganciclovir (GCV) were killed when challenged with vesicular stomatitis virus G glycoprotein pseudotyped HIV-1-based virus-like particles (VLPs) carrying the Nef7 (i.e., an HIV-1 Nef mutant incorporating in virions at high levels)/herpes simplex virus-1 thymidine kinase (HSV-TK) fusion product. On this basis, a novel anti-HIV therapeutic approach based on Nef7/TK VLPs expressing X4 or R5 HIV cell receptor complexes has been attempted. We here report that (CD4-CXCR4) and (CD4-CCR5) Nef7-based VLPs efficiently enter cells infected by X4- or R5-tropic HIV-1 strains, respectively. Importantly, the delivery of the VLP-associated Nef7/TK led to cell death upon GCV treatment. Of interest, VLPs were effective also against non-replicating, HIV-1-infected primary human monocyte-derived macrophages. HIV-targeted VLPs represent a promising candidate for the treatment of persistently HIV-1-infected cells that are part of virus reservoirs resistant to HAART therapies. | lld:pubmed |
| pubmed-article:16271741 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16271741 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16271741 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16271741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16271741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16271741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16271741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16271741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16271741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16271741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16271741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16271741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16271741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16271741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16271741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16271741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16271741 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16271741 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16271741 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:16271741 | pubmed:issn | 0042-6822 | lld:pubmed |
| pubmed-article:16271741 | pubmed:author | pubmed-author:SchiavoniIlar... | lld:pubmed |
| pubmed-article:16271741 | pubmed:author | pubmed-author:PuglieseKathe... | lld:pubmed |
| pubmed-article:16271741 | pubmed:author | pubmed-author:FedericoMauri... | lld:pubmed |
| pubmed-article:16271741 | pubmed:author | pubmed-author:PerettiSilvia... | lld:pubmed |
| pubmed-article:16271741 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16271741 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:16271741 | pubmed:volume | 345 | lld:pubmed |
| pubmed-article:16271741 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16271741 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16271741 | pubmed:pagination | 115-26 | lld:pubmed |
| pubmed-article:16271741 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:16271741 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16271741 | pubmed:articleTitle | Selective elimination of HIV-1-infected cells by Env-directed, HIV-1-based virus-like particles. | lld:pubmed |
| pubmed-article:16271741 | pubmed:affiliation | AIDS Center, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161 Rome, Italy. | lld:pubmed |
| pubmed-article:16271741 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16271741 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16271741 | lld:pubmed |
