Linked Life Data

16269317

Source:http://linkedlifedata.com/resource/pubmed/id/16269317

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2005-11-4
pubmed:abstractText
The corticotropin-releasing factor (CRF)-like peptides, which include the mammalian peptides CRF, urocortin 1, urocortin 2, and urocortin 3, play an important role in orchestrating behavioral and physiological responses that may increase an organism's chance of survival when confronted with internal or external stressors. There is, however, evidence that a chronic overactivity of brain CRF systems under basal conditions may play a role in the etiology and maintenance of psychiatric disorders such as depression and anxiety disorders. In addition, there is evidence of a role for CRF-like peptides in acute and protracted drug abstinence syndromes and relapse to drug-taking behavior. This review focuses on the role of CRF-like peptides in the negative affective state associated with acute and protracted withdrawal from three widely abused drugs, cannabis, nicotine, and alcohol. In addition, we discuss the high comorbidity between stress-associated psychiatric disorders and drug dependence. A better understanding of the brain stress systems that may underlie psychiatric disorders, acute and protracted drug withdrawal, and relapse to drug-taking behavior may help in the development of new and improved pharmacotherapies for these widespread psychiatric disorders.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:author
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
505-28
pubmed:dateRevised
2007-2-26
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
The role of corticotropin-releasing factor-like peptides in cannabis, nicotine, and alcohol dependence.
pubmed:affiliation
Department of Psychiatry, University of Florida, McKnight Brain Institute, 100 S. Newell Dr. PO Box 100256, Gainesville, FL 32610, USA. awbruijn@psychiatry.ufl.edu
pubmed:publicationType
Journal Article, Review