Linked Life Data

16269245

Source:http://linkedlifedata.com/resource/pubmed/id/16269245

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2005-11-25
pubmed:abstractText
Glucose has essential metabolic roles as both a fuel for energy and a substrate for the biosynthesis of cell components. Because of its central importance, many cells have evolved mechanisms to sense glucose levels in their environment and to adapt the expression of their genetic information to glucose availability. This glucose signaling is vital in mammalian cells where derangements in glucose utilization might contribute to conditions such as obesity and type 2 diabetes. Two crucial issues stand out in understanding pathways of glucose-regulated gene transcription. First, how do cells sense changing glucose levels? Second, how is this signal transduced to the transcriptional apparatus of the cell? In mammalian cells, glucose sensing involves the detection of changes in glucose metabolism rather than glucose itself. A transcription factor that is involved in mediating responses to glucose, ChREBP, has been identified recently and studies have begun to elucidate the molecular basis of coupling between glucose metabolism and transcription factor activity.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1043-2760
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
489-94
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Glucose as a regulator of eukaryotic gene transcription.
pubmed:affiliation
Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, 6-155 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA. towle@mail.ahc.umn.edu
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural