Linked Life Data

16269204

Source:http://linkedlifedata.com/resource/pubmed/id/16269204

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2006-1-31
pubmed:abstractText
Siberian hamsters express photoperiod-regulated seasonal cycles of body weight and food intake, providing an opportunity to study the role of melanocortin systems in regulating long-term adaptive changes in energy metabolism. These hamsters accumulate intraperitoneal fat reserves when kept in long summer photoperiods, but show a profound long-term decrease in food intake and body weight when exposed to a short winter photoperiod. Icv administration of a MC3/4-R agonist (MTII) potently suppresses food intake in hamsters in both the obese and lean state, indicating the potential for melanocortin systems to regulate energy metabolism in the hypothalamus of the Siberian hamster. Icv treatment with the melanocortin antagonist SHU9119 increases food intake in both seasonal states. Moreover, hamsters bearing neurotoxic lesions, which destroy the majority of POMC expressing neurons in the arcuate nucleus are still able to show seasonal regulation of body weight. These studies in a seasonal model substantiate the view that endogenous melanocortin systems exert a tonic inhibition of food intake in mammals. The observations that this melanocortin tone occurs to a similar extent in both an anabolic state induced by a long day photoperiod, and in a catabolic state induced by a short day photoperiod, suggests that alterations in endogenous melanocortin tone are not the primary cause of the lipolysis, weight-loss and hypophagia which characterize the establishment of the short day-induced overwintering state.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0196-9781
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
301-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Role of melanocortin in the long-term regulation of energy balance: lessons from a seasonal model.
pubmed:affiliation
School of Biomedical Sciences, University of Nottingham Medical School, Queens Medical Centre, Nottingham NG7 2UH, UK. alex.schuler@nottingham.ac.uk
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't