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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1992-6-12
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pubmed:abstractText |
Two double-blind four-way crossover studies are reported, comparing the antidepressant effect of 14-day courses of: viloxazine, viloxazine with a tranquillizer either perphenazine or diazepam or tranquillizer alone, against a placebo. In one study the antidepressant effect of viloxazine at a dose of 150 mg daily was statistically greater than that of placebo, whilst in the second study viloxazine was statistically superior to diazepam (15 mg daily). In depressed patients with a clear anxiety component, viloxazine alone seemed preferable to a combination with a tranquillizer as such a combination did not produce an enhanced clinical effect and the incidence of side-effects was possibly increased. Viloxazine was generally well tolerated and side-effects, when they occurred, were generally a mild upper gastro-intestinal disturbance.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0300-0605
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
3
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
207-13
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:162677-Depressive Disorder,
pubmed-meshheading:162677-Diazepam,
pubmed-meshheading:162677-Double-Blind Method,
pubmed-meshheading:162677-Drug Therapy, Combination,
pubmed-meshheading:162677-Female,
pubmed-meshheading:162677-Humans,
pubmed-meshheading:162677-Male,
pubmed-meshheading:162677-Middle Aged,
pubmed-meshheading:162677-Perphenazine,
pubmed-meshheading:162677-Placebos,
pubmed-meshheading:162677-Viloxazine
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pubmed:year |
1975
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pubmed:articleTitle |
A placebo controlled trial of viloxazine with and without tranquillizers in depressive illness.
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pubmed:affiliation |
Rubery Hill Hospital, Birmingham, England.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Controlled Clinical Trial
|