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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2005-11-3
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pubmed:abstractText |
GATA-3 was shown to bind to two sites of the IL-4 gene promoter in human T-cell lines PER-117 and Jurkat. A motif located in the region of position -860 and responsible for GATA-3 binding was detected for the first time. Mutation or deletion of this site increased the promoter activity. The findings suggest a direct involvement of GATA-3 in regulation of the human IL-4 gene transcription as a repressor of the promoter activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0006-2979
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1065-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16266280-Binding Sites,
pubmed-meshheading:16266280-Cells, Cultured,
pubmed-meshheading:16266280-Cytokines,
pubmed-meshheading:16266280-GATA3 Transcription Factor,
pubmed-meshheading:16266280-Gene Expression Regulation,
pubmed-meshheading:16266280-Genes, Reporter,
pubmed-meshheading:16266280-Humans,
pubmed-meshheading:16266280-Interleukin-4,
pubmed-meshheading:16266280-Jurkat Cells,
pubmed-meshheading:16266280-Promoter Regions, Genetic,
pubmed-meshheading:16266280-Protein Binding,
pubmed-meshheading:16266280-Repressor Proteins,
pubmed-meshheading:16266280-Th2 Cells,
pubmed-meshheading:16266280-Transcription, Genetic
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pubmed:year |
2005
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pubmed:articleTitle |
Transcription factor GATA-3 is involved in repression of promoter activity of the human interleukin-4 gene.
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pubmed:affiliation |
Curtin University School of Biomedical Sciences and the Western Australian Institute of Medical Research, Molecular Immunology Group, Perth, 6000, Western Australia, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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