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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-1-10
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pubmed:abstractText |
Combined pituitary hormone deficiency (CPHD) in humans is caused by mutations of pituitary-specific transcription factors such as Pit-1. Although many patients with CPHD have an autosomal recessive disorder caused by a Pit-1 DNA-binding mutation, there are a number of reports of mutant Pit-1 molecules that either by prediction or through experimentation bind normally to DNA.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0021-972X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
239-47
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16263824-Base Sequence,
pubmed-meshheading:16263824-Cells, Cultured,
pubmed-meshheading:16263824-Electrophoretic Mobility Shift Assay,
pubmed-meshheading:16263824-Genes, Reporter,
pubmed-meshheading:16263824-Humans,
pubmed-meshheading:16263824-Hypopituitarism,
pubmed-meshheading:16263824-Luciferases,
pubmed-meshheading:16263824-Models, Molecular,
pubmed-meshheading:16263824-Pituitary Hormones,
pubmed-meshheading:16263824-Protein Binding,
pubmed-meshheading:16263824-Transcription Factor Pit-1,
pubmed-meshheading:16263824-Transcriptional Activation,
pubmed-meshheading:16263824-Transfection,
pubmed-meshheading:16263824-p300-CBP Transcription Factors
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pubmed:year |
2006
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pubmed:articleTitle |
The role of CBP/p300 interactions and Pit-1 dimerization in the pathophysiological mechanism of combined pituitary hormone deficiency.
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pubmed:affiliation |
Section of Pediatric and Adult Endocrinology, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA. roncohen@medicine.bsd.uchicago.edu
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pubmed:publicationType |
Journal Article
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