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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-1-26
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pubmed:abstractText |
It is now well established that genetic factors play an important role in the pathogenesis of autism disorder and converging lines of evidence suggest the implication of the X chromosome. Using a sample of subjects diagnosed with autism spectrum disorders, exclusively composed of males from French-Canadian (FC) origin, we tested markers covering the entire X chromosome using a family-based association study. Our initial analysis revealed the presence of association at two loci: DXS6789 (P=0.026) and DXS8043 (P=0.0101). In a second step, we added support to the association at DXS8043 using additional markers, additional subjects and a haplotype-based analysis (best obtained P-value=0.00001). These results provide support for the existence of a locus on the X chromosome that predisposes the FC to autism spectrum disorders.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1359-4184
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pubmed:author |
pubmed-author:BonnetII,
pubmed-author:FombonneEE,
pubmed-author:Fri?PP,
pubmed-author:GariépyDD,
pubmed-author:GauthierJJ,
pubmed-author:JooberRR,
pubmed-author:LacasseHH,
pubmed-author:LaurentSS,
pubmed-author:MottronLL,
pubmed-author:NajafeeRR,
pubmed-author:RouleauG AGA,
pubmed-author:St-CharlesLL,
pubmed-author:St-OngeJJ
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
206-13
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16261168-Adolescent,
pubmed-meshheading:16261168-Adult,
pubmed-meshheading:16261168-Autistic Disorder,
pubmed-meshheading:16261168-Canada,
pubmed-meshheading:16261168-Child,
pubmed-meshheading:16261168-Child, Preschool,
pubmed-meshheading:16261168-Child Development Disorders, Pervasive,
pubmed-meshheading:16261168-Chromosome Mapping,
pubmed-meshheading:16261168-Chromosomes, Human, X,
pubmed-meshheading:16261168-Gene Frequency,
pubmed-meshheading:16261168-Genetic Markers,
pubmed-meshheading:16261168-Genetic Predisposition to Disease,
pubmed-meshheading:16261168-Genetics, Population,
pubmed-meshheading:16261168-Haplotypes,
pubmed-meshheading:16261168-Humans,
pubmed-meshheading:16261168-Linkage Disequilibrium,
pubmed-meshheading:16261168-Male,
pubmed-meshheading:16261168-Pedigree
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pubmed:year |
2006
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pubmed:articleTitle |
Autism spectrum disorders associated with X chromosome markers in French-Canadian males.
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pubmed:affiliation |
Centre Hospitalier de l'Université de Montréal, Research Centre, Notre Dame Hospital, Montreal, QC, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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