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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2005-10-31
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pubmed:abstractText |
Integrins and growth factor receptors coordinately regulate proliferation in nontransformed cells. Coordinate signaling from these receptors controls the activation of the G1 phase cyclin-dependent kinases, largely by regulating levels of cyclin D1 and p27(kip1). Induction of cyclin D1 is one of the best understood examples of an integrin/growth factor receptor-regulated G1 phase target. This review focuses on the integrin-dependent signal transduction events that regulate the expression of cyclin D1 during G1 phase.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0167-7659
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
383-93
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:16258726-Animals,
pubmed-meshheading:16258726-Cell Cycle,
pubmed-meshheading:16258726-Cyclin D1,
pubmed-meshheading:16258726-Cyclin-Dependent Kinase Inhibitor p27,
pubmed-meshheading:16258726-Disease Progression,
pubmed-meshheading:16258726-Extracellular Signal-Regulated MAP Kinases,
pubmed-meshheading:16258726-G1 Phase,
pubmed-meshheading:16258726-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16258726-Humans,
pubmed-meshheading:16258726-Integrins,
pubmed-meshheading:16258726-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:16258726-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:16258726-Signal Transduction
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pubmed:year |
2005
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pubmed:articleTitle |
Integrin-dependent signal transduction regulating cyclin D1 expression and G1 phase cell cycle progression.
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pubmed:affiliation |
Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6084, USA.
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pubmed:publicationType |
Journal Article,
Review,
Research Support, N.I.H., Extramural
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