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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2005-11-4
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pubmed:abstractText |
We found that platelet depletion reduces intrahepatic accumulation of virus-specific cytotoxic T lymphocytes (CTLs) and organ damage in mouse models of acute viral hepatitis. Transfusion of normal but not activation-blocked platelets in platelet-depleted mice restored accumulation of CTLs and severity of disease. In contrast, anticoagulant treatment that prevented intrahepatic fibrin deposition without reducing platelet counts did not avert liver injury. Thus, activated platelets contribute to CTL-mediated liver immunopathology independently of procoagulant function.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/AI40696,
http://linkedlifedata.com/resource/pubmed/grant/CA40489,
http://linkedlifedata.com/resource/pubmed/grant/HL31950,
http://linkedlifedata.com/resource/pubmed/grant/HL42846,
http://linkedlifedata.com/resource/pubmed/grant/HL78784,
http://linkedlifedata.com/resource/pubmed/grant/R01 NS042893-01A1,
http://linkedlifedata.com/resource/pubmed/grant/R01 NS054193-01A1,
http://linkedlifedata.com/resource/pubmed/grant/R01 NS057711-01A2,
http://linkedlifedata.com/resource/pubmed/grant/R01 NS061107-01A1,
http://linkedlifedata.com/resource/pubmed/grant/R21 NS054143-01A2,
http://linkedlifedata.com/resource/pubmed/grant/U01 NS052465-01A2
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16258538-10666256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16258538-10706630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16258538-11244031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16258538-11259841,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16258538-11748277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16258538-12941029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16258538-15085195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16258538-15324742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16258538-15487943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16258538-7612225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16258538-8144915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16258538-8574849
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1078-8956
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1167-9
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pubmed:dateRevised |
2010-12-17
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pubmed:meshHeading |
pubmed-meshheading:16258538-Animals,
pubmed-meshheading:16258538-Blood Platelets,
pubmed-meshheading:16258538-Cell Count,
pubmed-meshheading:16258538-Cytotoxicity, Immunologic,
pubmed-meshheading:16258538-Disease Models, Animal,
pubmed-meshheading:16258538-Hepatitis B,
pubmed-meshheading:16258538-Hepatitis B virus,
pubmed-meshheading:16258538-Liver,
pubmed-meshheading:16258538-Liver Diseases,
pubmed-meshheading:16258538-Mice,
pubmed-meshheading:16258538-Mice, Inbred C57BL,
pubmed-meshheading:16258538-Mice, Transgenic,
pubmed-meshheading:16258538-Platelet Activation,
pubmed-meshheading:16258538-Severity of Illness Index,
pubmed-meshheading:16258538-T-Lymphocytes, Cytotoxic
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pubmed:year |
2005
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pubmed:articleTitle |
Platelets mediate cytotoxic T lymphocyte-induced liver damage.
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pubmed:affiliation |
Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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