Linked Life Data

16258285

Source:http://linkedlifedata.com/resource/pubmed/id/16258285

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2005-12-16
pubmed:abstractText
Aurora-C is the third member of the aurora serine/threonine kinase family and was found only in mammals. Because Aurora-C is overexpressed in many different types of cancer cells we decided to analyze the consequences of Aurora-C overexpression in human cells. We first investigated the subcellular localization of overexpressed GFP-Aurora-C in mitosis and interphase in HeLa cells. As expected, during mitosis, we found that Aurora-C mimics Aurora-B. Surprisingly, in few interphase cells, we found that Aurora-C localized to the centrosome, like Aurora-A. We then examined the phenotype generated by Aurora-C overexpression. Basically it looked similar to the phenotypes observed after overexpression of the other Aurora kinases. We observed an augmentation of polyploid cells containing more than two centrosomes. More interestingly this phenotype was aggravated in the absence of a functional p53. Although the physiological function of Aurora-C in somatic cells remains to be clarified, our results, just like for the two other Aurora kinases, raised the question of a role of Aurora-C in the development and progression of cancer especially in the presence of mutated p53.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1551-4005
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1783-7
pubmed:dateRevised
2011-7-11
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
The absence of p53 aggravates polyploidy and centrosome number abnormality induced by Aurora-C overexpression.
pubmed:affiliation
CNRS UMR6061, Génétique et Développement, Université de Rennes 1, IFR140, Groupe Cycle Cellulaire, Equipe Labellisée Ligue Nationale Contre Le Cancer, Faculté de Médecine, Rennes, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't