|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0006118,
umls-concept:C0006826,
umls-concept:C0008059,
umls-concept:C0041700,
umls-concept:C0105770,
umls-concept:C0278510,
umls-concept:C0449438,
umls-concept:C0681842,
umls-concept:C1257890,
umls-concept:C1274040,
umls-concept:C2603343,
umls-concept:C2699414
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|
pubmed:issue |
31
|
|
pubmed:dateCreated |
2005-10-31
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|
pubmed:abstractText |
Identifying pathobiological correlates of clinical behavior or therapeutic response currently represents a key challenge for medulloblastoma research. Nuclear accumulation of the beta-catenin protein is associated with activation of the Wnt/Wg signaling pathway, and mutations affecting components of this pathway have been reported in approximately 15% of sporadic medulloblastomas. We tested the hypothesis that nuclear immunoreactivity for beta-catenin is a prognostic marker in medulloblastoma, and assessed the relationship between nuclear beta-catenin immunoreactivity and mutations of CTNNB1 and APC.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0732-183X
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
23
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
7951-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16258095-Adenomatous Polyposis Coli Protein,
pubmed-meshheading:16258095-Adolescent,
pubmed-meshheading:16258095-Cell Nucleus,
pubmed-meshheading:16258095-Cerebellar Neoplasms,
pubmed-meshheading:16258095-Child,
pubmed-meshheading:16258095-Child, Preschool,
pubmed-meshheading:16258095-Cytoplasm,
pubmed-meshheading:16258095-DNA Mutational Analysis,
pubmed-meshheading:16258095-Female,
pubmed-meshheading:16258095-Great Britain,
pubmed-meshheading:16258095-Humans,
pubmed-meshheading:16258095-Immunoenzyme Techniques,
pubmed-meshheading:16258095-Male,
pubmed-meshheading:16258095-Medulloblastoma,
pubmed-meshheading:16258095-Mutation,
pubmed-meshheading:16258095-Polymerase Chain Reaction,
pubmed-meshheading:16258095-Prognosis,
pubmed-meshheading:16258095-Survival Rate,
pubmed-meshheading:16258095-beta Catenin
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|
pubmed:year |
2005
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|
pubmed:articleTitle |
beta-Catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour Committee.
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|
pubmed:affiliation |
Northern Institute for Cancer Research, University of Newcastle, UK. D.W.Ellison@ncl.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
