rdf:type |
|
lifeskim:mentions |
umls-concept:C0007595,
umls-concept:C0013081,
umls-concept:C0015127,
umls-concept:C0018270,
umls-concept:C0027100,
umls-concept:C0033572,
umls-concept:C0035696,
umls-concept:C0086418,
umls-concept:C0162597,
umls-concept:C0851285,
umls-concept:C1166769,
umls-concept:C1314792,
umls-concept:C1510411
|
pubmed:issue |
5
|
pubmed:dateCreated |
2005-10-31
|
pubmed:abstractText |
SMemb/non-muscle myosin heavy chain B (SMemb/NMMHC-B) is most abundantly expressed in proliferating smooth muscle cells and correlates with phenotypic changes from a contractive to a proliferative type. The stromal cells of the prostate play a crucial role in the regulation of prostatic growth and function. The aim of this study was to investigate the effects of the multifunctional cytokine transforming growth factor-beta1 (TGF-beta1) on SMemb/NMMHC-B mRNA expression and stromal cell growth. The expression of the SM2 isoform of smooth muscle myosin heavy chain (SMMHC) mRNA was also examined.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:issn |
0036-5599
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
39
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
366-71
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:16257837-Cell Count,
pubmed-meshheading:16257837-Cell Proliferation,
pubmed-meshheading:16257837-Cells, Cultured,
pubmed-meshheading:16257837-Down-Regulation,
pubmed-meshheading:16257837-Humans,
pubmed-meshheading:16257837-Immunohistochemistry,
pubmed-meshheading:16257837-Male,
pubmed-meshheading:16257837-Myosin Heavy Chains,
pubmed-meshheading:16257837-Nonmuscle Myosin Type IIB,
pubmed-meshheading:16257837-Polymerase Chain Reaction,
pubmed-meshheading:16257837-Prostate,
pubmed-meshheading:16257837-RNA, Messenger,
pubmed-meshheading:16257837-Stromal Cells,
pubmed-meshheading:16257837-Transforming Growth Factor beta,
pubmed-meshheading:16257837-Transforming Growth Factor beta1
|
pubmed:year |
2005
|
pubmed:articleTitle |
Transforming growth factor-beta1 regulates cell growth and causes downregulation of SMemb/non-muscle myosin heavy chain B mRNA in human prostate stromal cells.
|
pubmed:affiliation |
Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan. obarak@med.niigata-u.ac.jp
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|