| pubmed-article:16257509 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16257509 | lifeskim:mentions | umls-concept:C0010222 | lld:lifeskim |
| pubmed-article:16257509 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:16257509 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:16257509 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:16257509 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:16257509 | pubmed:dateCreated | 2006-5-15 | lld:pubmed |
| pubmed-article:16257509 | pubmed:abstractText | Recent genetic evidence demonstrated that Shc is a critical molecule for T cell activation and differentiation. However, how Shc is coupled to the T cell antigen receptor (TCR) has not been clearly characterized. Here we report that the tyrosine kinase Lck functions as a connecting molecule for TCR and Shc. Lck plays a critical role in TCR signal transduction by phosphorylating the immuno-receptor tyrosine based activation motif (ITAM). Our data shows that the PTB domain of Shc binds the SH2/3 domains of Lck in a phosphotyrosine-independent manner. Inhibition of the Lck/Shc interaction led to the loss of IL-2 promoter activation, confirming that the role of Shc in IL-2 production requires its interaction with Lck. Together, the data show that Shc is connected to the activated TCR via direct interaction with Lck. | lld:pubmed |
| pubmed-article:16257509 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16257509 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16257509 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16257509 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16257509 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16257509 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16257509 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16257509 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16257509 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16257509 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16257509 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16257509 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16257509 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16257509 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16257509 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16257509 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16257509 | pubmed:issn | 0898-6568 | lld:pubmed |
| pubmed-article:16257509 | pubmed:author | pubmed-author:IwashimaMakio... | lld:pubmed |
| pubmed-article:16257509 | pubmed:author | pubmed-author:TakamatsuMasa... | lld:pubmed |
| pubmed-article:16257509 | pubmed:author | pubmed-author:HatanakaYasue... | lld:pubmed |
| pubmed-article:16257509 | pubmed:author | pubmed-author:FukushimaAtsu... | lld:pubmed |
| pubmed-article:16257509 | pubmed:author | pubmed-author:SinghNagendra... | lld:pubmed |
| pubmed-article:16257509 | pubmed:author | pubmed-author:ChangJing-Wen... | lld:pubmed |
| pubmed-article:16257509 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16257509 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:16257509 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16257509 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16257509 | pubmed:pagination | 1182-9 | lld:pubmed |
| pubmed-article:16257509 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:16257509 | pubmed:meshHeading | pubmed-meshheading:16257509... | lld:pubmed |
| pubmed-article:16257509 | pubmed:meshHeading | pubmed-meshheading:16257509... | lld:pubmed |
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| pubmed-article:16257509 | pubmed:meshHeading | pubmed-meshheading:16257509... | lld:pubmed |
| pubmed-article:16257509 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16257509 | pubmed:articleTitle | Lck couples Shc to TCR signaling. | lld:pubmed |
| pubmed-article:16257509 | pubmed:affiliation | Immunotherapy Center, Institute of Molecular Medicine and Genetics Medical College of Georgia, 1120 15th Street, Augusta, GA 30912-2600, USA. | lld:pubmed |
| pubmed-article:16257509 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16257509 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16257509 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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