Linked Life Data

16257509

Source:http://linkedlifedata.com/resource/pubmed/id/16257509

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2006-5-15
pubmed:abstractText
Recent genetic evidence demonstrated that Shc is a critical molecule for T cell activation and differentiation. However, how Shc is coupled to the T cell antigen receptor (TCR) has not been clearly characterized. Here we report that the tyrosine kinase Lck functions as a connecting molecule for TCR and Shc. Lck plays a critical role in TCR signal transduction by phosphorylating the immuno-receptor tyrosine based activation motif (ITAM). Our data shows that the PTB domain of Shc binds the SH2/3 domains of Lck in a phosphotyrosine-independent manner. Inhibition of the Lck/Shc interaction led to the loss of IL-2 promoter activation, confirming that the role of Shc in IL-2 production requires its interaction with Lck. Together, the data show that Shc is connected to the activated TCR via direct interaction with Lck.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0898-6568
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1182-9
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:16257509-Adaptor Proteins, Signal Transducing, pubmed-meshheading:16257509-Animals, pubmed-meshheading:16257509-COS Cells, pubmed-meshheading:16257509-Cercopithecus aethiops, pubmed-meshheading:16257509-Humans, pubmed-meshheading:16257509-Interleukin-2, pubmed-meshheading:16257509-Jurkat Cells, pubmed-meshheading:16257509-Lymphocyte Specific Protein Tyrosine Kinase p56(lck), pubmed-meshheading:16257509-Membrane Proteins, pubmed-meshheading:16257509-Models, Biological, pubmed-meshheading:16257509-Phosphotyrosine, pubmed-meshheading:16257509-Promoter Regions, Genetic, pubmed-meshheading:16257509-Protein Binding, pubmed-meshheading:16257509-Protein Structure, Tertiary, pubmed-meshheading:16257509-Receptors, Antigen, T-Cell, pubmed-meshheading:16257509-Shc Signaling Adaptor Proteins, pubmed-meshheading:16257509-Signal Transduction
pubmed:year
2006
pubmed:articleTitle
Lck couples Shc to TCR signaling.
pubmed:affiliation
Immunotherapy Center, Institute of Molecular Medicine and Genetics Medical College of Georgia, 1120 15th Street, Augusta, GA 30912-2600, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural