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pubmed-article:16257206pubmed:abstractTextTramadol is a centrally acting opioid analgesic structurally related to codeine and morphine. Analogs of tramadol with deuterium-for-hydrogen replacement at metabolically active sites were prepared and evaluated in vitro and in vivo.lld:pubmed
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pubmed-article:16257206pubmed:articleTitleDerivatives of tramadol for increased duration of effect.lld:pubmed
pubmed-article:16257206pubmed:affiliationSepracor Inc., 84 Waterford Drive, Marlborough, MA 01752, USA. liming.shao@sepracor.comlld:pubmed
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