Source:http://linkedlifedata.com/resource/pubmed/id/16256216
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-3
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pubmed:dateCreated |
2005-12-20
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pubmed:abstractText |
The vasodilating peptide adrenomedullin (AM) has been reported to regulate vascular tone as well as proliferation and differentiation of various cell types in an autocrine/paracrine manner. Our study was designed to investigate the effect of AM on Ang II-induced contraction on human aortic smooth muscle cells (HASMC) in vitro, evaluating the signal pathways involved. Our findings indicate that AM was able to inhibit HASMC Ang II-induced contraction (IC50 19 nM). AM stimulated cAMP production in a dose-dependent fashion as well. SQ 22.536, an adenylate cyclase inhibitor, and KT5720, a PKA inhibitor, blunted the AM effect, suggesting that it was mediated by the activation of the cAMP transduction pathway. Our results suggest that AM plays a role in the regulation of HASMC contraction by antagonizing the Ang II effects and may be involved in conditions of altered regulation of the blood vessels.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0167-0115
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
133
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
155-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16256216-Adrenomedullin,
pubmed-meshheading:16256216-Angiotensin II,
pubmed-meshheading:16256216-Aorta,
pubmed-meshheading:16256216-Cells, Cultured,
pubmed-meshheading:16256216-Dose-Response Relationship, Drug,
pubmed-meshheading:16256216-Humans,
pubmed-meshheading:16256216-Muscle Contraction,
pubmed-meshheading:16256216-Myocytes, Smooth Muscle,
pubmed-meshheading:16256216-Peptides,
pubmed-meshheading:16256216-Signal Transduction,
pubmed-meshheading:16256216-Vasodilator Agents
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pubmed:year |
2006
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pubmed:articleTitle |
Adrenomedullin inhibits angiotensin II-induced contraction in human aortic smooth muscle cells.
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pubmed:affiliation |
Dipartimento di Fisiopatologia Medica, V Clinica Medica, Policlinico Umberto I, Università La Sapienza Facoltà di Medicina, Viale del Policlinico, 00161 Rome, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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