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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2005-12-27
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pubmed:abstractText |
This study aimed at investigating if selective ex vivo immune deviation of myelin-specific cytokine secretion towards Th2 is possible in blood cells from patients with multiple sclerosis (MS). Interleukin (IL)-4 (Th2) and interferon-gamma (Th1) secreting cells were recorded by ELISPOT in 13 MS patients. Deviation was successful in 10 patients. Interleukin-4 alone was most effective in inducing myelin-specific immune deviation in MS patients whereas IL-1 or IL-15 in combination with IL-4 did not improve the results. Further studies and improvements are needed before ex vivo immune deviation can be considered a potential treatment in patients with MS.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0165-5728
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
171
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
156-62
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:16256209-Adult,
pubmed-meshheading:16256209-Aged,
pubmed-meshheading:16256209-Cell Culture Techniques,
pubmed-meshheading:16256209-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:16256209-Female,
pubmed-meshheading:16256209-Humans,
pubmed-meshheading:16256209-Immunization,
pubmed-meshheading:16256209-Interferon-gamma,
pubmed-meshheading:16256209-Interleukin-4,
pubmed-meshheading:16256209-Lymphocyte Activation,
pubmed-meshheading:16256209-Male,
pubmed-meshheading:16256209-Middle Aged,
pubmed-meshheading:16256209-Multiple Sclerosis,
pubmed-meshheading:16256209-Myelin Proteins,
pubmed-meshheading:16256209-Myelin Sheath,
pubmed-meshheading:16256209-Myelin-Associated Glycoprotein,
pubmed-meshheading:16256209-T-Lymphocytes,
pubmed-meshheading:16256209-Th2 Cells,
pubmed-meshheading:16256209-Time Factors
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pubmed:year |
2006
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pubmed:articleTitle |
In vitro Th2 deviation of myelin-specific peripheral blood lymphocytes from patients with multiple sclerosis.
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pubmed:affiliation |
Division of Clinical Immunology, Sweden.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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