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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-12-16
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pubmed:abstractText |
There is evidence to indicate that peripheral glucocorticoid receptor (GR) function is reduced in major depression, and a possible molecular explanation for this is the impact of raised pro-inflammatory cytokines. The topical steroid vasoconstriction assay provides a convenient probe of peripheral GR function. The present study sought to assess the sensitivity of peripheral GRs in antidepressant-resistant major depressives and investigate the association between GR sensitivity and circulating plasma cytokines.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0033-2917
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
37-43
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pubmed:dateRevised |
2007-8-13
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pubmed:meshHeading |
pubmed-meshheading:16255837-Adult,
pubmed-meshheading:16255837-Aged,
pubmed-meshheading:16255837-Antidepressive Agents,
pubmed-meshheading:16255837-Depressive Disorder, Major,
pubmed-meshheading:16255837-Drug Resistance,
pubmed-meshheading:16255837-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:16255837-Female,
pubmed-meshheading:16255837-Humans,
pubmed-meshheading:16255837-Hypersensitivity,
pubmed-meshheading:16255837-Interleukin-6,
pubmed-meshheading:16255837-Male,
pubmed-meshheading:16255837-Middle Aged,
pubmed-meshheading:16255837-Receptors, Glucocorticoid,
pubmed-meshheading:16255837-Severity of Illness Index,
pubmed-meshheading:16255837-Skin,
pubmed-meshheading:16255837-Tumor Necrosis Factor-alpha,
pubmed-meshheading:16255837-Vasoconstriction
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pubmed:year |
2006
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pubmed:articleTitle |
Cutaneous glucocorticoid receptor sensitivity and pro-inflammatory cytokine levels in antidepressant-resistant depression.
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pubmed:affiliation |
Department of Psychiatry & Alimentary Pharmabiotic Centre, University College Cork, Ireland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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