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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2005-12-12
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pubmed:abstractText |
Cigarette smoking is the primary cause of bronchogenic carcinoma (BC), yet only 10-15% of heavy smokers develop BC and it is likely that this variation in risk is, in part, genetically determined. We previously reported a set of antioxidant genes for which transcript abundance was lower in normal bronchial epithelial cells (NBEC) of BC individuals compared to non-BC individuals. In unpublished studies of the same NBEC samples, transcript abundance values for several DNA repair genes were correlated with these antioxidant genes. From these data, we hypothesized that antioxidant and DNA repair genes are co-regulated by one or more transcription factors and that inter-individual variation in expression and/or function of one or more of these transcription factors is responsible for inter-individual variation in risk for BC.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16255782-10749130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16255782-10891549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16255782-11799067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16255782-12054630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16255782-12177065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16255782-12496041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16255782-1339300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16255782-14705493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16255782-1486868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16255782-14970455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16255782-15177551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16255782-15735727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16255782-16088748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16255782-6290784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16255782-7501458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16255782-8242618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16255782-8532532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16255782-8533150
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/CCAAT-Enhancer-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/CCAAT-enhancer-binding protein-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/DNA excision repair protein ERCC-5,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Endonucleases,
http://linkedlifedata.com/resource/pubmed/chemical/GSTP1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Peroxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione S-Transferase pi,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxide Dismutase,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/X-ray repair cross complementing...,
http://linkedlifedata.com/resource/pubmed/chemical/glutathione peroxidase GPX1,
http://linkedlifedata.com/resource/pubmed/chemical/superoxide dismutase 1
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2407
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
141
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16255782-Adult,
pubmed-meshheading:16255782-Aged,
pubmed-meshheading:16255782-Aged, 80 and over,
pubmed-meshheading:16255782-Antioxidants,
pubmed-meshheading:16255782-Binding Sites,
pubmed-meshheading:16255782-Bronchi,
pubmed-meshheading:16255782-Bronchial Neoplasms,
pubmed-meshheading:16255782-CCAAT-Enhancer-Binding Proteins,
pubmed-meshheading:16255782-Carcinoma,
pubmed-meshheading:16255782-DNA Repair,
pubmed-meshheading:16255782-DNA-Binding Proteins,
pubmed-meshheading:16255782-Endonucleases,
pubmed-meshheading:16255782-Epithelial Cells,
pubmed-meshheading:16255782-Female,
pubmed-meshheading:16255782-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16255782-Glutathione Peroxidase,
pubmed-meshheading:16255782-Glutathione S-Transferase pi,
pubmed-meshheading:16255782-Humans,
pubmed-meshheading:16255782-Male,
pubmed-meshheading:16255782-Middle Aged,
pubmed-meshheading:16255782-Models, Statistical,
pubmed-meshheading:16255782-Nuclear Proteins,
pubmed-meshheading:16255782-Polymerase Chain Reaction,
pubmed-meshheading:16255782-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16255782-Sex Factors,
pubmed-meshheading:16255782-Smoking,
pubmed-meshheading:16255782-Superoxide Dismutase,
pubmed-meshheading:16255782-Transcription, Genetic,
pubmed-meshheading:16255782-Transcription Factors
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pubmed:year |
2005
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pubmed:articleTitle |
CEBPG transcription factor correlates with antioxidant and DNA repair genes in normal bronchial epithelial cells but not in individuals with bronchogenic carcinoma.
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pubmed:affiliation |
Department of Medicine, Medical University of Ohio, Room 0012 Ruppert Health Building, Toledo, OH 43614, USA. damullins@meduohio.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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