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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2005-11-15
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pubmed:abstractText |
The human kallikrein 10 (KLK10)/normal epithelial cell-specific-1 (NES1) gene is highly expressed in normal mammary, ovary and prostate cells, but its expression is dramatically decreased in cancer cell lines. Recently, it has been shown that CpG island hypermethylation of the KLK10 gene is responsible for the tumor-specific loss of KLK10 gene expression in certain breast cancer cell lines.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1010-4283
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2005 S. Karger AG, Basel.
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
324-36
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16254462-Breast Neoplasms,
pubmed-meshheading:16254462-Cell Line, Tumor,
pubmed-meshheading:16254462-CpG Islands,
pubmed-meshheading:16254462-Cytosine,
pubmed-meshheading:16254462-DNA Methylation,
pubmed-meshheading:16254462-Down-Regulation,
pubmed-meshheading:16254462-Exons,
pubmed-meshheading:16254462-Female,
pubmed-meshheading:16254462-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16254462-Humans,
pubmed-meshheading:16254462-Kallikreins,
pubmed-meshheading:16254462-Male,
pubmed-meshheading:16254462-Ovarian Neoplasms,
pubmed-meshheading:16254462-Prostatic Neoplasms,
pubmed-meshheading:16254462-RNA, Messenger
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pubmed:articleTitle |
Downregulation of human kallikrein 10 (KLK10/NES1) by CpG island hypermethylation in breast, ovarian and prostate cancers.
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pubmed:affiliation |
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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