Linked Life Data

16254133

Source:http://linkedlifedata.com/resource/pubmed/id/16254133

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2006-1-23
pubmed:abstractText
The phosphodiesterase-4 (PDE4) inhibitors may be an important target in the treatment of several inflammatory conditions. The anti-inflammatory effect of PDE4 inhibitors bears similarities with that of steroids, without interfering with the hypophysary-adrenal-axis. We compared the effect of rolipram, a selective PDE4 inhibitor, with steroids on the clinical course of experimental colitis induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS). Three groups of rats (n = 20) received TNBS. One group received methylprednisolone from day 7, another group received rolipram from the same day, and control group received no further treatment. On days 14 and 21 after TNBS instillation, sets of 10 rats underwent colonic dialysis to measure eicosanoid release. Colonic lesions were blindly scored, and colons were homogenized for quantification of myeloperoxidase (MPO) activity and collagen content. Concentration of tumor necrosis factor alpha (TNF-alpha) and transforming growth factor beta1 (TGF-beta1) in colonic tissue was also measured. Both treatments reduced significantly the eicosanoid release and MPO activity. On day 14, both rolipram and methylprednisolone significantly reduced TNF-alpha content, but TGF-beta1 was only inhibited by rolipram. On day 21, lesion scores and collagen content were significantly reduced only in rolipram-treated group. In conclusion, PDE4 inhibition by rolipram markedly ameliorates the course of chronic colitis and it is superior to methylprednisolone in preventing late collagen deposition.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0022-3565
pubmed:author
pubmed:issnType
Print
pubmed:volume
316
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
940-5
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:16254133-3',5'-Cyclic-AMP Phosphodiesterases, pubmed-meshheading:16254133-Animals, pubmed-meshheading:16254133-Chronic Disease, pubmed-meshheading:16254133-Colitis, pubmed-meshheading:16254133-Colon, pubmed-meshheading:16254133-Cyclic Nucleotide Phosphodiesterases, Type 4, pubmed-meshheading:16254133-Disease Models, Animal, pubmed-meshheading:16254133-Fibrosis, pubmed-meshheading:16254133-Male, pubmed-meshheading:16254133-Methylprednisolone, pubmed-meshheading:16254133-Peroxidase, pubmed-meshheading:16254133-Phosphodiesterase Inhibitors, pubmed-meshheading:16254133-Rats, pubmed-meshheading:16254133-Rats, Sprague-Dawley, pubmed-meshheading:16254133-Rolipram, pubmed-meshheading:16254133-Transforming Growth Factor beta, pubmed-meshheading:16254133-Transforming Growth Factor beta1, pubmed-meshheading:16254133-Tumor Necrosis Factor-alpha
pubmed:year
2006
pubmed:articleTitle
Selective inhibition of phosphodiesterase-4 ameliorates chronic colitis and prevents intestinal fibrosis.
pubmed:affiliation
Digestive System Research Unit, Hospital Vall d'Hebron, Barcelona, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't