Source:http://linkedlifedata.com/resource/pubmed/id/16253637
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
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| pubmed:dateCreated |
2005-10-28
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| pubmed:abstractText |
Cyclo (his-pro), controlled-energy diet, soy protein hydrolysate (SPH), and raw vegetable food (RVF) are known to improve insulin sensitivity and body weight (BW) control. Enhancement of high cyclo (his-pro) content in SPH (HCS) was performed by refluxing SPH with 1 N KH(2)CO(3) dissolved in 70% ethanol for 2 weeks at room temperature. Using this material, we examined the effects of HCS plus RVF on glucose metabolism and BW control in genetically diabetic Goto-Kakizaki (G-K) and insulin-resistant aged overweight Sprague-Dawley (S-D) rats. Thirty 7-week-old G-K rats and 18 16- to 18-month-old S-D rats were divided into 3 groups and treated with normal chow (NC), RVF diet, or HCS diet for 8 weeks. Raw vegetable food diet was made of 1:3 RVF and 2:3 NC; HCS diet was made of 1:27 portion HCS, 8:27 RVF, and 2:3 NC. Oral glucose tolerance significantly improved in both RVF- (P<.01) and HCS-treated (P<.001) G-K rats and worsened in NC-fed rats compared with the baseline values. Similarly, oral glucose tolerance also improved in aged overweight S-D rats when treated with RVF (P<.05) and with HCS (P<.01), compared with the baseline values. Although HCS diet treatment very significantly lowered fed plasma insulin levels compared with NC diet treatment in G-K rats (P<.01), RVF diet treatment alone did not decrease plasma insulin levels. In contrast, there was no change of insulin levels in overweight aged S-D rats after either RVF or HCS diet treatment. Postfeeding glucose levels in G-K rats fed RVF or HCS significantly fell, compared with the rats fed NC (P<.05). Interestingly, fasting blood glucose levels in RVF- or HCS-fed rats were very significantly lower than in NC-fed rats (P<.001). There was no change of blood glucose levels in S-D rats due to treatments with different diet. In G-K rats, food intake did not decrease during the first 3 weeks but fell very significantly from the fifth to eighth weeks with RVF (P<.01) and HCS (P<.001) treatments in G-K rats. However, food intake reduction in aged S-D rats was shown only for the HCS-treated rat group (P<.05). Water intake slightly decreased in G-K rats with either RVF or HCS treatment (P<.05) but very significantly decreased in S-D rats with HCS treatment (P<.01). Body weight gain in young G-K rats and BW in aged S-D rats significantly decreased only when rats were treated with HCS diet (P<.05). These data suggest that regular consumption of HCS diet helps to control blood glucose metabolism in diabetic G-K rats and BW control in aged obese S-D rats.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides, Cyclic,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Zinc,
http://linkedlifedata.com/resource/pubmed/chemical/histidyl-proline diketopiperazine
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| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
0026-0495
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
54
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1480-9
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:16253637-Aging,
pubmed-meshheading:16253637-Animal Feed,
pubmed-meshheading:16253637-Animals,
pubmed-meshheading:16253637-Antioxidants,
pubmed-meshheading:16253637-Blood Glucose,
pubmed-meshheading:16253637-Body Weight,
pubmed-meshheading:16253637-Diabetes Mellitus, Type 2,
pubmed-meshheading:16253637-Drinking,
pubmed-meshheading:16253637-Eating,
pubmed-meshheading:16253637-Energy Metabolism,
pubmed-meshheading:16253637-Female,
pubmed-meshheading:16253637-Glucose Tolerance Test,
pubmed-meshheading:16253637-Insulin,
pubmed-meshheading:16253637-Insulin Resistance,
pubmed-meshheading:16253637-Kidney,
pubmed-meshheading:16253637-Liver,
pubmed-meshheading:16253637-Male,
pubmed-meshheading:16253637-Obesity,
pubmed-meshheading:16253637-Peptides, Cyclic,
pubmed-meshheading:16253637-Piperazines,
pubmed-meshheading:16253637-Rats,
pubmed-meshheading:16253637-Rats, Inbred Strains,
pubmed-meshheading:16253637-Vegetables,
pubmed-meshheading:16253637-Zinc
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| pubmed:year |
2005
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| pubmed:articleTitle |
Raw vegetable food containing high cyclo (his-pro) improved insulin sensitivity and body weight control.
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| pubmed:affiliation |
Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. moon.song2@med.va.gov.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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