Source:http://linkedlifedata.com/resource/pubmed/id/16251897
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2005-12-16
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| pubmed:abstractText |
Interindividual variation of the IGF2-INS-TH region influences risk of a variety of diseases and complex traits. Previous studies identified a haplotype (designated IGF2-INS-TH(*)5 and tagged by allele A of IGF2 ApaI, allele 9 of TH01 and class I alleles of INS VNTR) associated with low body mass index (BMI) in a cohort of UK men. We aimed here both to study whether previous findings relating (*)5 with weight are replicated in a different cohort of men (East Hertfordshire) characterised in more phenotypic detail and to test the effect of this haplotype on related subphenotypes. The PHASE program was used to identify (*)5 and not(*)5 haplotypes. A total of 490 haplotypes were derived from 131 men and 114 women, the frequency of (*)5 being around 9%. Specific tests of (*)5 haplotype (vs not(*)5 haplotypes) conducted included Student's t-test and multiple regression analyses. We observed replication of weight effect for the (*)5 haplotype in men: significant associations with lower BMI (-1.81 kg/m(2), P=0.009), lower waist circumference (-6.3 cm, P=0.001) and lower waist-hip ratio (-5%, P<0.001). This haplotype also marks nearly two-fold lower 120 min insulin (P=0.004) as well as low baseline insulin (-11.02 pmol/l, P=0.043) and low 30 min insulin (-64.44 pmol/l, P=0.072) in a glucose tolerance test. No association between (*)5 and these traits was found in women. Our results, taken together with other data on IGFII levels and TH activity, point to the importance of (*)5 as an integrated polygenic haplotype relevant to obesity and insulin response to glucose in men.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/IGF2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor II,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine 3-Monooxygenase
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
1018-4813
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
14
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
109-16
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:16251897-Aged,
pubmed-meshheading:16251897-Birth Weight,
pubmed-meshheading:16251897-Body Mass Index,
pubmed-meshheading:16251897-Cohort Studies,
pubmed-meshheading:16251897-European Continental Ancestry Group,
pubmed-meshheading:16251897-Female,
pubmed-meshheading:16251897-Glucose Tolerance Test,
pubmed-meshheading:16251897-Haplotypes,
pubmed-meshheading:16251897-Humans,
pubmed-meshheading:16251897-Infant, Newborn,
pubmed-meshheading:16251897-Insulin,
pubmed-meshheading:16251897-Insulin-Like Growth Factor II,
pubmed-meshheading:16251897-Male,
pubmed-meshheading:16251897-Middle Aged,
pubmed-meshheading:16251897-Multigene Family,
pubmed-meshheading:16251897-Obesity,
pubmed-meshheading:16251897-Phenotype,
pubmed-meshheading:16251897-Proteins,
pubmed-meshheading:16251897-Regression Analysis,
pubmed-meshheading:16251897-Sex Factors,
pubmed-meshheading:16251897-Tyrosine 3-Monooxygenase
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| pubmed:year |
2006
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| pubmed:articleTitle |
Replication of IGF2-INS-TH*5 haplotype effect on obesity in older men and study of related phenotypes.
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| pubmed:affiliation |
Human Genetics Division, University of Southampton, School of Medicine, Southampton General Hospital, Southampton, UK.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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