Source:http://linkedlifedata.com/resource/pubmed/id/16251889
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2005-12-16
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pubmed:abstractText |
Adrenergic receptors regulate lipid mobilization, energy expenditure and glycogen breakdown. The beta(2) adrenergic receptor (beta(2)-AR) gene may constitute a potential candidate gene to explain part of the genetic predisposition to human obesity and correlated traits. With regard to the association between beta(2)-AR gene polymorphisms and obesity-related metabolic disorders, published reports give conflicting results. We investigated the role of three polymorphisms, and related haplotypes of the beta(2)-AR in the obesity and related traits in a cohort of overweight/obese subjects. We characterized one single nucleotide polymorphism (SNP) in the promoter region (5'LC-Cys19Arg) and two in the coding region (Gly16Arg and Gln27Glu) of the beta(2)-AR in 642 consecutively recruited overweight/obese subjects in whom extensive clinical and biochemical analysis was performed. The effect of the polymorphisms on quantitative variables was investigated using multiple linear regression analysis. 5'LC-Cys19 homozygous showed higher triglyceride and LDL-cholesterol levels compared to 5'LC-Arg19 homozygous (P=0.03 and P=0.01, respectively). Similar increase in triglyceride and LDL-cholesterol levels was observed for Arg/Arg genotype compared to Gly/Gly genotype of Gly16Arg polymorphism (P=0.02 and P=0.01, respectively) and for Gln/Gln genotype compared to Glu/Glu genotype of the Gln27Glu polymorphism (P=0.01 and P=0.03, respectively). The 5'LC-Cys(19)Arg(16)Gln(27) haplotype determined a significant increase in triglyceride and LDL-cholesterol levels compared to 5'LC-Arg(19)Gly(16)Glu(27) haplotype (P=0.05 and P=0.02, respectively). Our findings provide additional weight to previous observations on the influence of these three genetic variants on lipid phenotypes; particularly on the increase of triglycerides and LDL-cholesterol levels in overweight/obese subjects carrying the 5'LC-Cys(19)Arg(16)Gln(27) haplotype.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1018-4813
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pubmed:author |
pubmed-author:BuzzettiRaffaellaR,
pubmed-author:Di MarioUmbertoU,
pubmed-author:Di PietroSergioS,
pubmed-author:GalganiAndreaA,
pubmed-author:IacobellisGianlucaG,
pubmed-author:LeonettiFridaF,
pubmed-author:PetroneAntonioA,
pubmed-author:VaniaAndreaA,
pubmed-author:ZampettiSimonaS,
pubmed-author:ZavarellaSaraS
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
94-100
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16251889-Cholesterol, LDL,
pubmed-meshheading:16251889-Cohort Studies,
pubmed-meshheading:16251889-Female,
pubmed-meshheading:16251889-Gene Frequency,
pubmed-meshheading:16251889-Haplotypes,
pubmed-meshheading:16251889-Humans,
pubmed-meshheading:16251889-Italy,
pubmed-meshheading:16251889-Linkage Disequilibrium,
pubmed-meshheading:16251889-Male,
pubmed-meshheading:16251889-Obesity,
pubmed-meshheading:16251889-Overweight,
pubmed-meshheading:16251889-Polymorphism, Genetic,
pubmed-meshheading:16251889-Polymorphism, Single Nucleotide,
pubmed-meshheading:16251889-Promoter Regions, Genetic,
pubmed-meshheading:16251889-Receptors, Adrenergic, beta-2,
pubmed-meshheading:16251889-Triglycerides
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pubmed:year |
2006
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pubmed:articleTitle |
Association of beta2 adrenergic receptor polymorphisms and related haplotypes with triglyceride and LDL-cholesterol levels.
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pubmed:affiliation |
Endocrinology, Department of Clinical Sciences, University La Sapienza, Rome, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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