Source:http://linkedlifedata.com/resource/pubmed/id/16251627
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
2005-10-27
|
| pubmed:abstractText |
The aim of the present study was to evaluate the relation between iron status and cancer in a population of middle-aged adults living in France where iron supplementation and iron-fortified foods are rarely used. The SU.VI.MAX study is a randomized, double-blind, placebo-controlled primary prevention trial evaluating the effect of antioxidant supplementation on chronic diseases in women aged 35-60 and men aged 45-60 y. At baseline, concentrations of hemoglobin, serum transferrin and serum ferritin were measured in 10,197 subjects. Data on dietary intake were estimated from six 24-h dietary records completed during the first 2 study years and available for 5287 subjects. All cancer cases that occurred during the 7.5-y follow-up were validated. In men, baseline serum transferrin and serum ferritin concentrations did not differ between subjects with cancers (n = 467) and those without. In women, serum ferritin was higher (P < 0.0001) and serum transferrin tended to be lower (P < 0.08) in cancer cases. Iron status was not related to cancer risk in men, but women with serum ferritin concentrations > 160 microg/L had an increased risk of cancer (odds ratio = 1.88, 95% CI: 1.05,3.35). No relation was found between dietary iron intake and risk of all cancer sites combined for either men or women. Our results suggest that iron status is not a predictor of cancer risk in men, whereas a serum ferritin concentration > 160 microg/L may be associated with an increase in cancer risk in women.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Ferritins,
http://linkedlifedata.com/resource/pubmed/chemical/Iron,
http://linkedlifedata.com/resource/pubmed/chemical/Placebos,
http://linkedlifedata.com/resource/pubmed/chemical/Transferrin
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0022-3166
|
| pubmed:author |
pubmed-author:BertraisSandrineS,
pubmed-author:BriançonSergeS,
pubmed-author:CzernichowSébastienS,
pubmed-author:EstaquioCarlaC,
pubmed-author:FavierAlainA,
pubmed-author:GalanPilarP,
pubmed-author:HercbergSergeS,
pubmed-author:MennenLouiseL,
pubmed-author:NoisetteNathalieN,
pubmed-author:RenversezJean-CharlesJC
|
| pubmed:issnType |
Print
|
| pubmed:volume |
135
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2664-8
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:16251627-Adult,
pubmed-meshheading:16251627-Age Factors,
pubmed-meshheading:16251627-Antioxidants,
pubmed-meshheading:16251627-Diet,
pubmed-meshheading:16251627-Double-Blind Method,
pubmed-meshheading:16251627-Female,
pubmed-meshheading:16251627-Ferritins,
pubmed-meshheading:16251627-France,
pubmed-meshheading:16251627-Humans,
pubmed-meshheading:16251627-Iron,
pubmed-meshheading:16251627-Male,
pubmed-meshheading:16251627-Middle Aged,
pubmed-meshheading:16251627-Neoplasms,
pubmed-meshheading:16251627-Nutritional Status,
pubmed-meshheading:16251627-Placebos,
pubmed-meshheading:16251627-Risk Factors,
pubmed-meshheading:16251627-Sex Factors,
pubmed-meshheading:16251627-Smoking,
pubmed-meshheading:16251627-Transferrin
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
Iron status and risk of cancers in the SU.VI.MAX cohort.
|
| pubmed:affiliation |
U557 Inserm (UMR Inserm/Inra/CNAM), Institut Scientifique et Technique de la Nutrition et de l'Alimentation/CNAM, F-75003 Paris, France. hercberg@cnam.fr
|
| pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|