Source:http://linkedlifedata.com/resource/pubmed/id/16249427
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
11
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pubmed:dateCreated |
2005-10-26
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pubmed:abstractText |
The ATP-sensitive K+ channel (K ATP channel) senses metabolic changes in the pancreatic beta-cell, thereby coupling metabolism to electrical activity and ultimately to insulin secretion. When K ATP channels open, beta-cells hyperpolarize and insulin secretion is suppressed. The prediction that K ATP channel "overactivity" should cause a diabetic state due to undersecretion of insulin has been dramatically borne out by recent genetic studies implicating "activating" mutations in the Kir6.2 subunit of K ATP channel as causal in human diabetes. This article summarizes the emerging picture of K ATP channel as a major cause of neonatal diabetes and of a polymorphism in K ATP channel (E23K) as a type 2 diabetes risk factor. The degree of K ATP channel "overactivity" correlates with the severity of the diabetic phenotype. At one end of the spectrum, polymorphisms that result in a modest increase in K ATP channel activity represent a risk factor for development of late-onset diabetes. At the other end, severe "activating" mutations underlie syndromic neonatal diabetes, with multiple organ involvement and complete failure of glucose-dependent insulin secretion, reflecting K ATP channel "overactivity" in both pancreatic and extrapancreatic tissues.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0012-1797
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3065-72
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:16249427-Adenosine Triphosphate,
pubmed-meshheading:16249427-Animals,
pubmed-meshheading:16249427-Diabetes Mellitus,
pubmed-meshheading:16249427-Humans,
pubmed-meshheading:16249427-Insulin,
pubmed-meshheading:16249427-Mutation,
pubmed-meshheading:16249427-Potassium Channels, Inwardly Rectifying
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pubmed:year |
2005
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pubmed:articleTitle |
Diabetes and insulin secretion: the ATP-sensitive K+ channel (K ATP) connection.
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pubmed:affiliation |
Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA. jkoster@cellbio.wustl.edu
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pubmed:publicationType |
Journal Article,
Review,
Research Support, N.I.H., Extramural
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