Linked Life Data

16248258

Source:http://linkedlifedata.com/resource/pubmed/id/16248258

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
34
pubmed:dateCreated
2005-10-26
pubmed:abstractText
Do genetic (G), or environmental (E), factors primarily determine blood lipid concentrations in the Geneva population? On-going research on the causes of hypercholesterolemia in populations based on data collected by the Bus Santé Survey is summarized. About 2/3 of the HDL-cholesterol variance could not be explained by the most important 5 of 10 environmental factors and 9 of 275 common genetic variants identified in the analyses. The remaining 1/3 of the variance was explained mainly by obesity, smoking, alcohol intake, age, and gender. The common polymorphisms played a much smaller role. GxG, GxE, and ExE interactions were the weakest determinants. Environmental factors appear to be the main determinants of hypercholesterolemia in populations. Measurement of genetic traits for clinical or public health purposes is currently not useful.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1660-9379
pubmed:author
pubmed:issnType
Print
pubmed:day
28
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2198-202, 2204
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
[Determinants of hypercholesterolemia in Geneva: should the focus be on genes or environment?].
pubmed:affiliation
Service d'epidémiologie clinique, Hôpitaux universitaires de Genève, 1211 Genève 14. Alfredo.Morabia@hcuge.ch
pubmed:publicationType
Journal Article, English Abstract