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16248019
Source:
http://linkedlifedata.com/resource/pubmed/id/16248019
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Predicate
Object
rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0038477
,
umls-concept:C0050795
,
umls-concept:C0243071
,
umls-concept:C0243077
pubmed:issue
5-7
pubmed:dateCreated
2005-10-26
pubmed:abstractText
Four 5'-substituted fluoro-neplanocin A analogues la-d were designed and synthesized, and the inhibitory activity against SAH was in the following order: NH2 > SH > F, N3, indicating a hydrogen bonding donor is essential for inhibitory activity.
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/100892832
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine
,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosylhomocysteinase
,
http://linkedlifedata.com/resource/pubmed/chemical/Antiviral Agents
,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors
,
http://linkedlifedata.com/resource/pubmed/chemical/Hydrogen
,
http://linkedlifedata.com/resource/pubmed/chemical/neplanocin A
pubmed:status
MEDLINE
pubmed:issn
1525-7770
pubmed:author
pubmed-author:ChunMoon WooMW
,
pubmed-author:JeongLak ShinLS
,
pubmed-author:LeeJoo HyunJH
,
pubmed-author:LeeKang ManKM
,
pubmed-author:LeeSang KookSK
,
pubmed-author:MoonHyung RyongHR
,
pubmed-author:ParkSeung BinSB
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
707-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:16248019-Adenosine
,
pubmed-meshheading:16248019-Adenosylhomocysteinase
,
pubmed-meshheading:16248019-Antiviral Agents
,
pubmed-meshheading:16248019-Catalysis
,
pubmed-meshheading:16248019-Chemistry, Pharmaceutical
,
pubmed-meshheading:16248019-Drug Design
,
pubmed-meshheading:16248019-Enzyme Inhibitors
,
pubmed-meshheading:16248019-Hydrogen
,
pubmed-meshheading:16248019-Hydrogen Bonding
,
pubmed-meshheading:16248019-Inhibitory Concentration 50
,
pubmed-meshheading:16248019-Models, Chemical
,
pubmed-meshheading:16248019-Structure-Activity Relationship
,
pubmed-meshheading:16248019-Temperature
pubmed:year
2005
pubmed:articleTitle
Structure-activity relationship of 5'-substituted fluoro-neplanocin a analogues as potent inhibitors of S-adenosylhomocysteine hydrolase.
pubmed:affiliation
College of Pharmacy, Pusan National University, Pusan 609-735, Korea.
pubmed:publicationType
Journal Article
,
Research Support, Non-U.S. Gov't