Linked Life Data

16247556

Source:http://linkedlifedata.com/resource/pubmed/id/16247556

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2005-10-25
pubmed:abstractText
Abscisic acid-responsive gene expression is regulated by numerous transcription factors, including a subgroup of basic leucine zipper factors that bind to the conserved cis-acting sequences known as ABA-responsive elements. Although one of these factors, ABA-insensitive 5 (ABI5), was identified genetically, the paucity of genetic data for the other family members has left it unclear whether they perform unique functions or act redundantly to ABI5 or each other. To test for potential redundancy with ABI5, we identified the family members with most similar effects and interactions in transient expression systems (ABF3 and ABF1), then characterized loss-of-function lines for those loci. The abf1 and abf3 monogenic mutant lines had at most minimal effects on germination or seed-specific gene expression, but the enhanced ABA- and stress-resistance of abf3 abi5 double mutants revealed redundant action of these genes in multiple stress responses of seeds and seedlings. Although ABI5, ABF3, and ABF1 have some overlapping effects, they appear to antagonistically regulate each other's expression at specific stages. Consequently, loss of any one factor may be partially compensated by increased expression of other family members.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0167-4412
pubmed:author
pubmed:issnType
Print
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
253-67
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:16247556-Abscisic Acid, pubmed-meshheading:16247556-Arabidopsis, pubmed-meshheading:16247556-Arabidopsis Proteins, pubmed-meshheading:16247556-Basic-Leucine Zipper Transcription Factors, pubmed-meshheading:16247556-Dose-Response Relationship, Drug, pubmed-meshheading:16247556-Gene Deletion, pubmed-meshheading:16247556-Gene Expression Profiling, pubmed-meshheading:16247556-Gene Expression Regulation, Developmental, pubmed-meshheading:16247556-Gene Expression Regulation, Plant, pubmed-meshheading:16247556-Genes, Reporter, pubmed-meshheading:16247556-Germination, pubmed-meshheading:16247556-Multigene Family, pubmed-meshheading:16247556-Promoter Regions, Genetic, pubmed-meshheading:16247556-Seedling, pubmed-meshheading:16247556-Sodium Chloride, pubmed-meshheading:16247556-Sorbitol, pubmed-meshheading:16247556-Transcriptional Activation
pubmed:year
2005
pubmed:articleTitle
Redundant and distinct functions of the ABA response loci ABA-INSENSITIVE(ABI)5 and ABRE-BINDING FACTOR (ABF)3.
pubmed:affiliation
Molecular, Cellular, and Developmental Biology Department, University of California at Santa Barbara, Santa Barbara, CA 93106, USA. finkelst@lifesci.ucsb.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't