Source:http://linkedlifedata.com/resource/pubmed/id/16246555
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2005-12-26
|
| pubmed:abstractText |
The synthesis of a series of maslinic acid derivatives is described and their effect on rabbit muscle glycogen phosphorylase a evaluated. Within this series of compounds, 15 (IC(50)=7 microM) is the most potent GPa inhibitor. SAR of the maslinic acid derivatives are discussed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
722-6
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:16246555-Animals,
pubmed-meshheading:16246555-Enzyme Inhibitors,
pubmed-meshheading:16246555-Glycogen Phosphorylase, Muscle Form,
pubmed-meshheading:16246555-Muscles,
pubmed-meshheading:16246555-Rabbits,
pubmed-meshheading:16246555-Structure-Activity Relationship,
pubmed-meshheading:16246555-Triterpenes
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Pentacyclic triterpenes. Part 2: Synthesis and biological evaluation of maslinic acid derivatives as glycogen phosphorylase inhibitors.
|
| pubmed:affiliation |
Department of Medicinal Chemistry, College of Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Evaluation Studies
|