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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-11-18
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pubmed:abstractText |
A new inhibitor of p53-HDM2 interaction was isolated from a culture of marine-derived fungus, Arthrinium sp. The structure was identified to be (-)-hexylitaconic acid (1) by spectroscopic analysis. The inhibition of p53-HDM2 binding was tested by the ELISA method, and 1 inhibited the binding with an IC(50) value of 50 microg/mL. Although a number of synthetic inhibitors of p53-HDM2 interaction have been reported so far, 1 is the second inhibitor isolated from natural resources.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
69-71
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16246554-Ascomycota,
pubmed-meshheading:16246554-Chemistry, Pharmaceutical,
pubmed-meshheading:16246554-Crystallography, X-Ray,
pubmed-meshheading:16246554-Dose-Response Relationship, Drug,
pubmed-meshheading:16246554-Drug Design,
pubmed-meshheading:16246554-Enzyme Inhibitors,
pubmed-meshheading:16246554-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:16246554-Fungal Proteins,
pubmed-meshheading:16246554-Humans,
pubmed-meshheading:16246554-Inhibitory Concentration 50,
pubmed-meshheading:16246554-Models, Chemical,
pubmed-meshheading:16246554-Protein Binding,
pubmed-meshheading:16246554-Proto-Oncogene Proteins c-mdm2,
pubmed-meshheading:16246554-Succinates,
pubmed-meshheading:16246554-Tumor Suppressor Protein p53
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pubmed:year |
2006
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pubmed:articleTitle |
Hexylitaconic acid: a new inhibitor of p53-HDM2 interaction isolated from a marine-derived fungus, Arthrinium sp.
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pubmed:affiliation |
Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920-1192, Japan. sachiko@p.kanazawa-u.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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