Linked Life Data

16243795

Source:http://linkedlifedata.com/resource/pubmed/id/16243795

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pubmed-article:16243795pubmed:abstractTextBcl-2 is a model apoptosis suppressor postulated to promote tumorigenesis. Recently, it has been reported that Bcl-2 undergoes phosphoregulation of its Ser70 to substantially alter its molecular function. Previous studies further suggest that such phospho-Bcl-2 regulation may influence tumor progression in colorectal and other cancers; however, phosphorylation status of the Ser70 of Bcl-2 (pSer70) in vivo in tumors remains obscure. To elucidate this question that may suggest the biological role, we molecularly screened a panel of human colorectal adenomas and adenocarcinomas for endogenous expression of pSer70 Bcl-2.lld:pubmed
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pubmed-article:16243795pubmed:articleTitleExpression of phosphorylated Ser70 of Bcl-2 correlates with malignancy in human colorectal neoplasms.lld:pubmed
pubmed-article:16243795pubmed:affiliationDepartment of Pathology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan. ekondo@md.okayama-u.ac.jplld:pubmed
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