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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
20
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pubmed:dateCreated |
2005-10-24
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pubmed:abstractText |
Bcl-2 is a model apoptosis suppressor postulated to promote tumorigenesis. Recently, it has been reported that Bcl-2 undergoes phosphoregulation of its Ser70 to substantially alter its molecular function. Previous studies further suggest that such phospho-Bcl-2 regulation may influence tumor progression in colorectal and other cancers; however, phosphorylation status of the Ser70 of Bcl-2 (pSer70) in vivo in tumors remains obscure. To elucidate this question that may suggest the biological role, we molecularly screened a panel of human colorectal adenomas and adenocarcinomas for endogenous expression of pSer70 Bcl-2.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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|
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:IchimuraKoichiK,
pubmed-author:IwagakiHiromiH,
pubmed-author:KimuraToshikazuT,
pubmed-author:KondoEisakuE,
pubmed-author:MiyakeTakayoshiT,
pubmed-author:NakamuraShin-IchiS,
pubmed-author:OharaNobuyaN,
pubmed-author:OkaTakashiT,
pubmed-author:ShibasakiFutoshiF,
pubmed-author:ShibataMasaoM,
pubmed-author:TanakaTakehiroT,
pubmed-author:YanaiHiroyukiH,
pubmed-author:YoshinoTadashiT
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pubmed:issnType |
Print
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pubmed:day |
15
|
|
pubmed:volume |
11
|
|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
7255-63
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16243795-Adenocarcinoma,
pubmed-meshheading:16243795-Adenoma,
pubmed-meshheading:16243795-Antibody Specificity,
pubmed-meshheading:16243795-Apoptosis,
pubmed-meshheading:16243795-Cell Cycle,
pubmed-meshheading:16243795-Cell Line, Tumor,
pubmed-meshheading:16243795-Colorectal Neoplasms,
pubmed-meshheading:16243795-Female,
pubmed-meshheading:16243795-Humans,
pubmed-meshheading:16243795-Immunoblotting,
pubmed-meshheading:16243795-Immunohistochemistry,
pubmed-meshheading:16243795-Ki-67 Antigen,
pubmed-meshheading:16243795-Lymphatic Metastasis,
pubmed-meshheading:16243795-Male,
pubmed-meshheading:16243795-Middle Aged,
pubmed-meshheading:16243795-Mutation,
pubmed-meshheading:16243795-Neoplasm Staging,
pubmed-meshheading:16243795-Phosphorylation,
pubmed-meshheading:16243795-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:16243795-Serine,
pubmed-meshheading:16243795-Survival Analysis,
pubmed-meshheading:16243795-Transfection
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pubmed:year |
2005
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pubmed:articleTitle |
Expression of phosphorylated Ser70 of Bcl-2 correlates with malignancy in human colorectal neoplasms.
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pubmed:affiliation |
Department of Pathology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan. ekondo@md.okayama-u.ac.jp
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pubmed:publicationType |
Journal Article,
Comparative Study
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