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rdf:type |
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lifeskim:mentions |
umls-concept:C0030705,
umls-concept:C0085862,
umls-concept:C0086345,
umls-concept:C0205292,
umls-concept:C0332120,
umls-concept:C0439659,
umls-concept:C0476073,
umls-concept:C1299583,
umls-concept:C1306837,
umls-concept:C1549571,
umls-concept:C1608386
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pubmed:issue |
20
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pubmed:dateCreated |
2005-10-24
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pubmed:abstractText |
In patients with papillary renal cell carcinoma, it is not uncommon to find two or more anatomically distinct and histologically similar tumors at radical nephrectomy. Whether these multiple papillary lesions result from intrarenal metastasis or arise independently is unknown. Previous studies have shown that multifocal clear cell renal cell carcinomas express identical allelic loss and shift patterns in the different tumors within the same kidney, consistent with a clonal origin. However, similar clonality assays for multifocal papillary renal cell neoplasia have not been done. Molecular analysis of microsatellite and chromosome alterations and X-chromosome inactivation status in separate tumors in the same patient can be used to study the genetic relationships among the coexisting multiple tumors.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:BonsibStephen MSM,
pubmed-author:BrunelliMatteoM,
pubmed-author:ChengLiangL,
pubmed-author:DelahuntBrettB,
pubmed-author:EbleJohn NJN,
pubmed-author:JonesTimothy DTD,
pubmed-author:Lopez-BeltranAntonioA,
pubmed-author:MacLennanGregory TGT,
pubmed-author:MartignoniGuidoG,
pubmed-author:NigroKellyK,
pubmed-author:UlbrightThomas MTM,
pubmed-author:WangMingshengM,
pubmed-author:ZhangShaoboS
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7226-33
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pubmed:meshHeading |
pubmed-meshheading:16243792-Adult,
pubmed-meshheading:16243792-Aged,
pubmed-meshheading:16243792-Aged, 80 and over,
pubmed-meshheading:16243792-Carcinoma, Papillary,
pubmed-meshheading:16243792-Carcinoma, Renal Cell,
pubmed-meshheading:16243792-Chromosomes, Human, Pair 16,
pubmed-meshheading:16243792-Chromosomes, Human, Pair 17,
pubmed-meshheading:16243792-Chromosomes, Human, Pair 3,
pubmed-meshheading:16243792-Chromosomes, Human, Pair 7,
pubmed-meshheading:16243792-Chromosomes, Human, Pair 9,
pubmed-meshheading:16243792-Female,
pubmed-meshheading:16243792-Gene Frequency,
pubmed-meshheading:16243792-Humans,
pubmed-meshheading:16243792-In Situ Hybridization, Fluorescence,
pubmed-meshheading:16243792-Kidney Neoplasms,
pubmed-meshheading:16243792-Loss of Heterozygosity,
pubmed-meshheading:16243792-Male,
pubmed-meshheading:16243792-Microsatellite Repeats,
pubmed-meshheading:16243792-Middle Aged,
pubmed-meshheading:16243792-Models, Genetic,
pubmed-meshheading:16243792-Neoplasms, Multiple Primary,
pubmed-meshheading:16243792-Nephrectomy,
pubmed-meshheading:16243792-Trisomy,
pubmed-meshheading:16243792-X Chromosome Inactivation
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pubmed:year |
2005
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pubmed:articleTitle |
Molecular genetic evidence for the independent origin of multifocal papillary tumors in patients with papillary renal cell carcinomas.
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pubmed:affiliation |
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
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pubmed:publicationType |
Journal Article
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