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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2006-1-9
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pubmed:abstractText |
The antitumoral activity of a series of acetylated bis-tetrahydrofuranic acetogenins with a threo/trans/threo/trans/erythro relative configuration was characterized by four new natural and two semisynthetic, 15,24,30-trioxygenated acetogenins that were found to inhibit mitochondrial complex I enzyme as well as growth of several tumor cell lines. Placement of acetyl groups along the alkyl chain modulated the potency of the bis-tetrahydrofuranic acetogenins and could be important for future utilization of these compounds as chemotherapeutic agents.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0968-0896
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pubmed:author |
pubmed-author:BarrachinaIsabelI,
pubmed-author:ChahbouneNadiaN,
pubmed-author:CortesDiegoD,
pubmed-author:De PedroNuriaN,
pubmed-author:EstornellErnestoE,
pubmed-author:PeláezFernandoF,
pubmed-author:RomeroVanessaV,
pubmed-author:RoyoInmaculadaI,
pubmed-author:SáezJairoJ,
pubmed-author:TormoJosé RJR,
pubmed-author:Zafra-PoloM CarmenMC
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1089-94
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:16242335-Acetogenins,
pubmed-meshheading:16242335-Antineoplastic Agents,
pubmed-meshheading:16242335-Cell Line, Tumor,
pubmed-meshheading:16242335-Cell Proliferation,
pubmed-meshheading:16242335-Electron Transport Complex I,
pubmed-meshheading:16242335-Fatty Alcohols,
pubmed-meshheading:16242335-Growth Inhibitors,
pubmed-meshheading:16242335-Humans,
pubmed-meshheading:16242335-Lactones,
pubmed-meshheading:16242335-Magnetic Resonance Spectroscopy,
pubmed-meshheading:16242335-Molecular Structure,
pubmed-meshheading:16242335-Neoplasms,
pubmed-meshheading:16242335-Spectrometry, Mass, Electrospray Ionization,
pubmed-meshheading:16242335-Structure-Activity Relationship
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pubmed:year |
2006
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pubmed:articleTitle |
Guanaconetins, new antitumoral acetogenins, mitochondrial complex I and tumor cell growth inhibitors.
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pubmed:affiliation |
Departamento de Farmacología, Facultad de Farmacia, Universidad de Valencia, Burjassot, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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