Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2005-10-24
pubmed:abstractText
The effects of gastrin (G17) on the growth and migration factors of four human melanoma cell lines (HT-144, C32, G-361, and SKMEL-28) were investigated. The expression patterns of cholecystokinin (CCK)(A), CCK(B), and CCK(C) gastrin receptors were investigated in these cells and in seven clinical samples by means of reverse transcription polymerase chain reaction. Melanoma cells appear to express mRNA for CCK(C) receptors, but not for CCK(A) or CCK(B) receptors. Although gastrin does not significantly modify the growth characteristics of the cell lines under study, it significantly modifies their cell migration characteristics. These modifications occur at adhesion level by modifying the expression levels of alpha(v) and beta3 integrins, at motility level by modifying the organization of the actin cytoskeleton, and at invasion level by modifying the expression levels of matrix metalloproteinase 14. We recently demonstrated the presence of CCK(B) receptors in mouse endothelial cells involved in glioblastoma neoangiogenesis. Chronic in vivo administration of a selective CCK(B) receptor antagonist to mice bearing xenografts of human C32 melanoma cells significantly decreased levels of neoangiogenesis, resulting in considerable delays in the growth of these C32 xenografts. In conclusion, our study identifies the pleiotropic effects of gastrin on melanoma cell biology.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-10094466, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-10200463, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-10471536, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-10721490, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-10843728, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-10861447, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-11121041, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-11181948, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-11181951, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-11208554, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-11259608, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-11522618, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-11585772, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-11704826, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-11731431, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-11746774, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-11782382, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-11864912, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-11971760, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-12065727, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-12218085, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-12429993, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-12496470, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-12570855, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-12635172, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-12649266, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-12657185, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-12714585, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-12749865, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-12808113, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-12941789, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-14657486, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-15026323, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-15087394, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-15124132, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-15137052, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-15180500, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-15229476, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-15274073, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-15331357, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-15623601, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-15705890, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-15800333, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-1913642, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-3017969, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-6101907, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-7721737, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-8023165, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-8036989, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-8608589, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-8609660, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-8649838, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-9000580, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-9020360, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-9102227, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-9223295, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-9828043, http://linkedlifedata.com/resource/pubmed/commentcorrection/16242076-9989446
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Actins, http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, http://linkedlifedata.com/resource/pubmed/chemical/Cholecystokinin, http://linkedlifedata.com/resource/pubmed/chemical/Cisplatin, http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary, http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers, http://linkedlifedata.com/resource/pubmed/chemical/Dacarbazine, http://linkedlifedata.com/resource/pubmed/chemical/Gastrins, http://linkedlifedata.com/resource/pubmed/chemical/Poly(ADP-ribose) Polymerases, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Cholecystokinin B, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cholecystokinin
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1522-8002
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
930-43
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
More...