Linked Life Data

16242073

Source:http://linkedlifedata.com/resource/pubmed/id/16242073

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pubmed-article:16242073pubmed:abstractTextWe designed a fluorescent peptide-magnetic nanoparticle conjugate that images E-selectin expression in mouse xenograft models of Lewis lung carcinoma (LLC) by fluorescence reflectance imaging. It was synthesized by attaching the E-selectin-binding peptide (ESBP; CDSDSDITWDQLWDLMK) to a CLIO(Cy5.5) nanoparticle to yield ESBP-CLIO(Cy5.5). Internalization by activated human umbilical vein endothelial cells (HUVECs) was rapid and mediated by E-selectin, indicated by the lack of uptake of nanoparticles bearing similar numbers of a scrambled peptide (Scram). To demonstrate the specificity of E-selectin targeting to ESBP-CLIO(Cy5.5) in vivo, we coinjected ESBP-CLIO(Cy5.5) and Scram-CLIO(Cy3.5) and demonstrated a high Cy5.5/Cy3.5 fluorescence ratio using the LLC. Histology showed that ESBP-CLIO was associated with tumor cells as well as endothelial cells, but fluorescence-activated cell sorter analysis showed a far less expression of E-selectin on LLC than on HUVECs. Using immunohistochemistry, we demonstrated E-selectin expression in both endothelial cells and cancer cells in human prostate cancer specimens. We conclude that ESBP-CLIO(Cy5.5) is a useful probe for imaging E-selectin associated with the LLC tumor, and that E-selectin is expressed not only on endothelial cells but also on LLC cells and human prostate cancer specimens.lld:pubmed
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pubmed-article:16242073pubmed:articleTitleNanoparticles for the optical imaging of tumor E-selectin.lld:pubmed
pubmed-article:16242073pubmed:affiliationDepartment of Angiography and Interventional Radiology, Vienna Medical University, Vienna, Austria.lld:pubmed
pubmed-article:16242073pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16242073pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
pubmed-article:16242073pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed
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