Source:http://linkedlifedata.com/resource/pubmed/id/16240598
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2005-10-24
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| pubmed:abstractText |
Cigarette smoking and occupational exposure to respiratory irritants are the major riskfactors for chronic obstructive pulmonary disease (COPD), which is characterized by small-airway obstruction and destruction of pulmonary parenchyma: emphysema. We studied two groups of subjects: one exposed and the other one not-exposed to respiratory irritants, to investigate the relationship, if any, between occupational exposure and COPD. Subjects underwent high-resolution computed tomography-density mask of the chest to quantify pulmonary emphysema, pulmonary function tests, sputum induction and analysis for cell counts and measurements of metalloproteinase (MMP)-9 and its tissue inhibitor TIMP-1. Subjects with occupational exposure to respiratory irritants had higher residual volume and functional residual capacity, higher total inflammatory cells and neutrophils in induced sputum. By contrast, sputum levels of MMP-9, TIMP-1 and MMP-91TIMP-1 ratio did not differ between the 2 groups. We conclude that sputum induction and analysis could be a useful and non-invasive tool to study and follow subjects with occupational exposure to respiratory irritants.
|
| pubmed:language |
ita
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
1592-7830
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
27
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
370-2
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:16240598-Aged,
pubmed-meshheading:16240598-Cell Count,
pubmed-meshheading:16240598-Female,
pubmed-meshheading:16240598-Humans,
pubmed-meshheading:16240598-Irritants,
pubmed-meshheading:16240598-Male,
pubmed-meshheading:16240598-Metalloproteases,
pubmed-meshheading:16240598-Neutrophils,
pubmed-meshheading:16240598-Occupational Diseases,
pubmed-meshheading:16240598-Occupational Exposure,
pubmed-meshheading:16240598-Pulmonary Disease, Chronic Obstructive,
pubmed-meshheading:16240598-Pulmonary Emphysema,
pubmed-meshheading:16240598-Radiography, Thoracic,
pubmed-meshheading:16240598-Respiratory Function Tests,
pubmed-meshheading:16240598-Risk Factors,
pubmed-meshheading:16240598-Smoking,
pubmed-meshheading:16240598-Sputum,
pubmed-meshheading:16240598-Time Factors,
pubmed-meshheading:16240598-Tissue Inhibitor of Metalloproteinase-1,
pubmed-meshheading:16240598-Tomography, X-Ray Computed
|
| pubmed:articleTitle |
[Occupational exposure to respiratory irritants and chronic obstructive pulmonary disease].
|
| pubmed:affiliation |
Dipartimento di Medicina Clinica e Sperimentale, Sezione di Igiene e Medicina del Lavoro, Università di Ferrara. bsp@unife.it
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| pubmed:publicationType |
Journal Article,
Comparative Study,
English Abstract
|