Linked Life Data

16240505

Source:http://linkedlifedata.com/resource/pubmed/id/16240505

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2005-10-21
pubmed:abstractText
The hypothesis to be tested is that reduced cell-cell interactions between T cells and monocytes are one of the reasons for the observed depression of the "in vitro" activation of human lymphocytes in microgravity. Locomotion is essential for cell-cell contacts. Lymphocytes in suspension are highly motile in microgravity, whereas no data are available so far on the motility of adherent monocytes. It can be argued that an impaired locomotion of monocytes and cytoskeletal changes, both linked to cell contacts, could be responsible for their reduced interaction with T lymphocytes. This study is aimed at revealing how locomotion as well as cytoskeletal structures of adherent monocytes are modified under modeled microgravity conditions using the Random Positioning Machine (RPM, Dutch-Space) as earth based model of spaceflight.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
S
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1077-9248
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NASA
pubmed:authorsComplete
Y
pubmed:pagination
P197-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2004
pubmed:articleTitle
Modeled microgravity affects motility and cytoskeletal structures.
pubmed:affiliation
Dip. Scienze Fisiol. Bioch e Cellulari, Univ. Sassari, Sassar, Italy. melonima@uniss.it
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't