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16240002
Source:
http://linkedlifedata.com/resource/pubmed/id/16240002
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Statements in which the resource exists as a subject.
Predicate
Object
rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0030016
,
umls-concept:C0033262
,
umls-concept:C0205460
,
umls-concept:C0220781
,
umls-concept:C0243077
,
umls-concept:C0441655
,
umls-concept:C1883254
pubmed:issue
21
pubmed:dateCreated
2005-10-21
pubmed:abstractText
A series of palmarumycin prodrugs and water-soluble analogs has been synthesized and assayed for inhibition of the thioredoxin-thioredoxin reductase system. Increased aqueous solubility led to an improved in vivo activity profile.
pubmed:grant
http://linkedlifedata.com/resource/pubmed/grant/U19CA-52995
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/101154995
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents
,
http://linkedlifedata.com/resource/pubmed/chemical/Naphthalenes
,
http://linkedlifedata.com/resource/pubmed/chemical/Prodrugs
,
http://linkedlifedata.com/resource/pubmed/chemical/Spiro Compounds
,
http://linkedlifedata.com/resource/pubmed/chemical/Thioredoxin-Disulfide Reductase
,
http://linkedlifedata.com/resource/pubmed/chemical/Thioredoxins
,
http://linkedlifedata.com/resource/pubmed/chemical/palmarumycin C2
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1477-0520
pubmed:author
pubmed-author:BirminghamAnneA
,
pubmed-author:EnglundErikah EEE
,
pubmed-author:LynchStephen MSM
,
pubmed-author:PowisGarthG
,
pubmed-author:WipfPeterP
pubmed:issnType
Print
pubmed:day
7
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3880-2
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:16240002-Antineoplastic Agents
,
pubmed-meshheading:16240002-Cell Line, Tumor
,
pubmed-meshheading:16240002-Cell Proliferation
,
pubmed-meshheading:16240002-Drug Screening Assays, Antitumor
,
pubmed-meshheading:16240002-Humans
,
pubmed-meshheading:16240002-Naphthalenes
,
pubmed-meshheading:16240002-Prodrugs
,
pubmed-meshheading:16240002-Solubility
,
pubmed-meshheading:16240002-Spiro Compounds
,
pubmed-meshheading:16240002-Structure-Activity Relationship
,
pubmed-meshheading:16240002-Thioredoxin-Disulfide Reductase
,
pubmed-meshheading:16240002-Thioredoxins
pubmed:year
2005
pubmed:articleTitle
Synthesis and biological activity of prodrug inhibitors of the thioredoxin-thioredoxin reductase system.
pubmed:affiliation
Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA. pwipf@pitt.edu
pubmed:publicationType
Journal Article
,
Research Support, N.I.H., Extramural