Linked Life Data

16239477

Source:http://linkedlifedata.com/resource/pubmed/id/16239477

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5747
pubmed:dateCreated
2005-10-21
pubmed:abstractText
Positive feedback is a ubiquitous signal transduction motif that allows systems to convert graded inputs into decisive, all-or-none outputs. Here we investigate why the positive feedback switches that regulate polarization of budding yeast, calcium signaling, Xenopus oocyte maturation, and various other processes use multiple interlinked loops rather than single positive feedback loops. Mathematical simulations revealed that linking fast and slow positive feedback loops creates a "dual-time" switch that is both rapidly inducible and resistant to noise in the upstream signaling system.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1095-9203
pubmed:author
pubmed:issnType
Electronic
pubmed:day
21
pubmed:volume
310
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
496-8
pubmed:dateRevised
2011-9-20
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Interlinked fast and slow positive feedback loops drive reliable cell decisions.
pubmed:affiliation
Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, CA, 94305, USA. onn@stanford.edu
pubmed:publicationType
Journal Article