Source:http://linkedlifedata.com/resource/pubmed/id/16236498
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
24
|
| pubmed:dateCreated |
2005-11-1
|
| pubmed:abstractText |
Novel synthetic phospholipid compound 1 was discovered to be an antagonist of human toll-like receptor 2 (TLR2) signaling. In a preliminary SAR campaign we synthesized several analogues of 1 and found that considerable structural changes could be made without loss of TLR2 antagonistic activity.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
5494-8
|
| pubmed:meshHeading |
pubmed-meshheading:16236498-Humans,
pubmed-meshheading:16236498-Indicators and Reagents,
pubmed-meshheading:16236498-Kinetics,
pubmed-meshheading:16236498-Models, Molecular,
pubmed-meshheading:16236498-Phospholipids,
pubmed-meshheading:16236498-Stereoisomerism,
pubmed-meshheading:16236498-Structure-Activity Relationship,
pubmed-meshheading:16236498-Toll-Like Receptor 2
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
Toll-like receptor 2 antagonists. Part 1: preliminary SAR investigation of novel synthetic phospholipids.
|
| pubmed:affiliation |
Lead Optimization Department, Eisai Research Institute, 100 Research Drive, Wilmington, MA 01887, USA. mark_spyvee@eisai.com
|
| pubmed:publicationType |
Journal Article
|