Linked Life Data

16235926

Source:http://linkedlifedata.com/resource/pubmed/id/16235926

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
22
pubmed:dateCreated
2005-10-20
pubmed:abstractText
[reaction: see text] The catalytic asymmetric hydrogenation of enamine amides and esters with catalyst Rh-1a, prepared from ferrocenyl based ligand 1a or 1b and [(COD)RhCl](2), has been shown through kinetic studies to suffer from product inhibition. Enamine ester substrates have also been shown to be incompatible with the amine products of the reaction in methanol. In situ protection of the amine products with di-tert-butyl dicarbonate eliminates functional group incompatibility of ester substrates and eliminates product inhibition in the reaction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1523-7060
pubmed:author
pubmed:issnType
Print
pubmed:day
27
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4935-8
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Detection and elimination of product inhibition from the asymmetric catalytic hydrogenation of enamines.
pubmed:affiliation
Department of Process Research, Merck Research Laboratories, Rahway, New Jersey 07065, USA. karl_hansen@merck.com
pubmed:publicationType
Journal Article